Research Article
Assessment of Safety Profile of Activated Curcumin C3 Complex (AC3®), Enriched Extract of Bisdemethoxycurcumin from the Rhizomes of Curcuma longa
Table 4
Effect of single dose oral gavage to AC3® on body weight and body weight change (%) in female Wistar rats.
| | Study type | Animal no. | Dose (mg/kg b.w) | Body weight (g) on day | Body weight change (%) on day | | 0 | 7 | 14 | 0 to 7 | 0 to 14 |
| | Step 1 | 1 | 2000 | 187.35 | 203.22 | 219.68 | 8.47 | 17.26 | | 2 | 179.47 | 195.15 | 208.23 | 8.74 | 16.02 | | 3 | 174.71 | 190.69 | 208.97 | 9.15 | 19.61 |
| | Mean ± SD | 180.51 ± 6.38 | 196.35 ± 6.35 | 212.29 ± 6.41 | 8.78 ± 0.34 | 17.63 ± 1.82 |
| | Step 2 | 4 | 2000 | 195.48 | 211.63 | 232.36 | 8.26 | 18.87 | | 5 | 183.20 | 199.87 | 214.87 | 9.10 | 17.29 | | 6 | 188.92 | 206.98 | 221.95 | 9.27 | 17.48 |
| | Mean ± SD | 189.20 ± 6.14 | 205.98 ± 5.89 | 223.06 ± 8.80 | 8.88 ± 0.54 | 17.88 ± 0.86 |
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Values are expressed as mean ± SD. Bold values highlight the mean values of the three readings of individual rodent.
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