Research Article
Assessment of Safety Profile of Activated Curcumin C3 Complex (AC3®), Enriched Extract of Bisdemethoxycurcumin from the Rhizomes of Curcuma longa
Table 13
Effect of AC3® on different parameters of reproductive/developmental toxicity study.
| | Observations | Values | | Dosage (units) | Vehicle control | Low dose-125 mg/kg b.w | Mid dose-250 mg/kg b.w | High dose-500 mg/kg b.w |
| | Pairs started (N) | 10 | 10 | 10 | 10 | | Females showing evidence of copulation (N) | 10 | 10 | 10 | 10 | | Females achieving pregnancy (N) | 10 | 10 | 09 | 10 | | Conceiving days 1–5 (N) | 3 | 4 | 3 | 6 | | Conceiving days ≥6 (N) | 7 | 6 | 6 | 4 | | Pregnancy ≤21 Days (N) | 3 | 2 | 2 | 2 | | Pregnancy = 22 Days (N) | 6 | 7 | 6 | 7 | | Pregnancy ≥23 Days (N) | 1 | 1 | 1 | 1 | | Dams with live young born (N) | 10 | 10 | 9 | 10 | | Dams with live young at day 4 PP (N) | 10 | 10 | 9 | 10 | | Implants/dam (mean) | 11.80 | 12.50 | 11.22 | 12.60 | | Live pups/dam at birth (mean) | 11.20 | 11.50 | 10.56 | 11.50 | | Live pups/dam at day 4 (mean) | 11.10 | 11.50 | 10.44 | 11.50 | | Sex ratio (M/F) at birth (mean) | 105.19 | 110.05 | 104.07 | 106.92 | | Sex ratio (M/F) at day 4 (mean) | 102.69 | 110.05 | 102.08 | 106.92 | | Litter weight at birth (mean) | 69.90 | 72.83 | 63.61 | 75.07 | | Litter weight at day 4 (mean) | 84.23 | 95.07 | 78.63 | 98.12 | | Pup weight at birth (mean) | 6.24 | 6.33 | 6.03 | 6.53 | | Pup weight at the time of AGD measurement (mean) male/females | M | 7.61 | 8.17 | 7.69 | 8.48 | | F | 7.55 | 8.37 | 7.57 | 8.59 | | Pup AGD on the same postnatal day, birth–day 4 (mean male/females note postnatal day) | M | 2.84 | 2.85 | 2.88 | 2.83 | | F | 1.82 | 1.84 | 1.86 | 1.83 | | Pup weight at day 4 (mean) | 7.59 | 8.27 | 7.58 | 8.53 | | Male pup nipple retention at day 13 (mean) | 0 | 0 | 0 | 0 | | Pup weight at day 13 (mean) | 18.72 | 19.09 | 19.73 | 19.91 | | Abnormal pups | | Dams with 0 (N) | 10 | 10 | 9 | 10 | | Dams with 1 (N) | 0 | 0 | 0 | 0 | | Dams with ≥2 (N) | 0 | 0 | 0 | 0 | | Loss of offspring | | Prenatal/postimplantations (implantations minus live births) | | Females with 0 | 6 | 3 | 7 | 7 | | Females with 1 | 3 | 4 | 1 | 1 | | Females with 2 | 0 | 3 | 1 | 2 | | Females with ≥3 | 1 | 0 | 1 | 0 | | Postnatal (live births minus alive at postnatal day 13) | | Females with 0 | 9 | 10 | 9 | 10 | | Females with 1 | 1 | 0 | 1 | 0 | | Females with 2 | 0 | 0 | 0 | 0 | | Females with ≥3 | 0 | 0 | 0 | 0 |
|
|
M: male; F: female; N: number; PP: postpartum; AGD: anogenital distance.
|
