Assessment of Safety Profile of Activated Curcumin C3 Complex (AC³®), Enriched Extract of Bisdemethoxycurcumin from the Rhizomes of Curcuma longa

Table 12

Effect of absolute organ weights (g) of animals in reproductive/developmental toxicity study of AC³®.

Treatment groups	Male			Female
	Testes	Epididymidis	Seminal vesicle & coagulation gland	Ovaries	Uterus with cervix
Vehicle control	2.997 ± 0.309	1.247 ± 0.097	1.948 ± 0.448	0.098 ± 0.014	0.471 ± 0.220
Low dose-125 mg/kg b.w	2.866 ± 0.403	1.175 ± 0.199	1.817 ± 0.492	0.103 ± 0.014	0.557 ± 0.225
Mid dose-250 mg/kg b.w	2.878 ± 0.477	1.143 ± 0.183	1.989 ± 0.383	0.085 ± 0.019	0.436 ± 0.113
High dose-500 mg/kg b.w	3.012 ± 0.371	1.278 ± 0.252	1.968 ± 0.346	0.088 ± 0.017	0.499 ± 0.410

Values are expressed as mean ± SD for the treatment groups. n = 10 (for both male and female animals).