Assessment of Safety Profile of Activated Curcumin C3 Complex (AC³®), Enriched Extract of Bisdemethoxycurcumin from the Rhizomes of Curcuma longa

Table 11

Effect of body weight (g) of female animals during gestation and lactation period in reproductive/developmental toxicity study of AC³®.

Treatment groups	Gestation period (days)				Lactation period (days)
	0	7	14	20	0	4	13
Vehicle control	244.07 ± 12.19	250.06 ± 12.32	272.82 ± 15.08	299.06 ± 22.90	221.78 ± 22.09	227.05 ± 21.84	243.97 ± 23.63
Low dose-125 mg/kg b.w	237.42 ± 9.76	243.84 ± 9.66	268.59 ± 7.59	302.36 ± 17.92	225.83 ± 17.45	232.56 ± 18.99	254.52 ± 16.73
Mid dose-250 mg/kg b.w	241.84 ± 10.94	252.63 ± 11.23	265.36 ± 10.77	295.95 ± 10.76	227.99 ± 14.15	235.28 ± 15.25	246.58 ± 14.18
High dose-500 mg/kg b.w	235.73 ± 9.77	246.09 ± 10.88	270.77 ± 17.64	300.61 ± 21.30	221.60 ± 15.49	230.61 ± 18.97	250.82 ± 18.18

Values are expressed as mean ± SD. n = 10 for vehicle control, low, and high dose; n = 9 for mid dose.