Assessment of Safety Profile of Activated Curcumin C3 Complex (AC³®), Enriched Extract of Bisdemethoxycurcumin from the Rhizomes of Curcuma longa

Table 10

Effect of 90 days exposure to AC³® on absolute organ weights (g) in Wistar rats.

Organs	Sex	Vehicle control	Treated			Control recovery	High dose-500 mg/kg b.w recovery
			Low dose-125 mg/kg b.w	Mid dose-250 mg/kg b.w	High dose-500 mg/kg b.w
Adrenals	M	0.060 ± 0.010	0.065 ± 0.010	0.069 ± 0.015	0.061 ± 0.011	0.055 ± 0.009	0.052 ± 0.007
	F	0.070 ± 0.010	0.073 ± 0.009	0.069 ± 0.016	0.058 ± 0.011	0.058 ± 0.006	0.059 ± 0.005
Liver	M	9.580 ± 1.070	9.473 ± 1.689	10.285 ± 1.192	9.717 ± 2.196	8.599 ± 1.286	8.812 ± 1.289
	F	6.765 ± 0.622	6.518 ± 0.689	6.510 ± 0.325	6.365 ± 0.870	6.060 ± 0.852	5.868 ± 1.015
Kidneys	M	1.970 ± 0.250	1.925 ± 0.288	2.111 ± 0.250	2.167 ± 0.303	2.022 ± 0.199	1.981 ± 0.351
	F	1.483 ± 0.213	1.320 ± 0.141	1.380 ± 0.216	1.443 ± 0.155	1.413 ± 0.225	1.337 ± 0.238
Heart	M	1.120 ± 0.120	1.056 ± 0.129	1.190 ± 0.188	1.141 ± 0.141	1.094 ± 0.246	1.088 ± 0.134
	F	0.725 ± 0.095	0.744 ± 0.096	0.775 ± 0.088	0.776 ± 0.074	0.749 ± 0.081	0.769 ± 0.125
Brain	M	1.830 ± 0.080	1.833 ± 0.162	1.893 ± 0.111	1.890 ± 0.089	1.860 ± 0.096	1.891 ± 0.103
	F	1.750 ± 0.081	1.742 ± 0.102	1.824 ± 0.158	1.797 ± 0.143	1.784 ± 0.071	1.808 ± 0.134
Spleen	M	0.830 ± 0.130	0.759 ± 0.227	0.771 ± 0.173	0.812 ± 0.202	0.702 ± 0.135	0.737 ± 0.097
	F	0.591 ± 0.283	0.607 ± 0.125	0.514 ± 0.127	0.526 ± 0.006	0.609 ± 0.171	0.536 ± 0.092
Thymus	M	0.290 ± 0.060	0.341 ± 0.077	0.300 ± 0.069	0.342 ± 0.112	0.276 ± 0.041	0.280 ± 0.090
	F	0.300 ± 0.086	0.296 ± 0.088	0.268 ± 0.100	0.276 ± 0.004	0.259 ± 0.087	0.261 ± 0.059
Thyroid parathyroid gland	M	0.020 ± 0.000	0.024 ± 0.005	0.026 ± 0.005	0.026 ± 0.007	0.022 ± 0.003	0.025 ± 0.004
	F	0.022 ± 0.006	0.024 ± 0.003	0.024 ± 0.005	0.023 ± 0.004	0.023 ± 0.002	0.022 ± 0.004
Pituitary gland	M	0.010 ± 0.000	0.011 ± 0.001	0.011 ± 0.001	0.011 ± 0.001	0.010 ± 0.001	0.013 ± 0.001
	F	0.013 ± 0.003	0.012 ± 0.002	0.013 ± 0.002	0.014 ± 0.011	0.011 ± 0.002	0.012 ± 0.002
Ovaries	F	0.174 ± 0.137	0.115 ± 0.023	0.242 ± 0.314	0.133 ± 0.030	0.110 ± 0.017	0.112 ± 0.012
Uterus with cervix	F	0.852 ± 0.348	0.813 ± 0.464	0.738 ± 0.325	0.736 ± 0.323	0.713 ± 0.178	0.621 ± 0.172
Testes	M	2.850 ± 0.430	3.059 ± 0.358	2.968 ± 0.297	3.138 ± 0.317	2.943 ± 0.258	3.115 ± 0.323
Prostate	M	0.660 ± 0.260	0.666 ± 0.224	0.776 ± 0.293	0.836 ± 0.397	0.827 ± 0.330	0.800 ± 0.248
Seminal vesicle with coagulation gland	M	1.050 ± 0.400	0.827 ± 0.248	0.960 ± 0.240	0.934 ± 0.293	0.914 ± 0.193	0.868 ± 0.212
Epididymis	M	1.390 ± 0.300	1.226 ± 0.241	1.231 ± 0.204	1.283 ± 0.188	1.279 ± 0.115	1.350 ± 0.255

Values are expressed as mean ± SD, n = 10. M: male; F: female. Significant from control recovery () in male.