Journal of Toxicology / 2019 / Article / Tab 2

Research Article

Histological, Biochemical, and Hematological Effects of Goniothalamin on Selective Internal Organs of Male Sprague-Dawley Rats

Table 2

Biochemical evaluation for acute toxicity.

Control100mg/kg200mg/kg300mg/kg400mg/kg500mg/kg

Creatinine (µmol/L)25.22 ± 1.1325.13 ± 1.1124.00 ± 2.1524.52 ± 2.1425.00 ± 1.2226.24 ± 1.14
Urea (mmol/L)5.95 ± 0.335.60 ± 0.155.87 ± 0.135.90 ± 0.215.91 ± 0.325.85 ± 0.15
Albumin (g/L)35.9 ± 3.234.6 ± 3.734.2 ± 7.834.3 ± 3.233.5 ± 5.333.2 ± 4.3
Globulin (g/L)23.2 ± 2.821.5 ± 1.822.3 ± 3.122.6 ± 2.921.2 ± 4.221.3 ± 3.9
Total bilirubin (µmol/L)2.0 ± 0.82.1 ± 0.72.0 ± 0.51.9 ± 0.41.9 ± 0.72.1 ± 0.9
Alkaline phosphatase (U/L)432 ± 11424 ± 29431 ± 26422 ± 13420 ± 14435 ± 17
Alanine aminotransferase (U/L)118 ± 31119 ± 11116 ± 21120 ± 10117 ± 18115 ± 12
Aspartate aminotransferase (U/L)153 ± 56155 ± 32153 ± 21152 ± 42155 ± 23152 ± 32

The results are expressed as the mean ±Standard error, (n=7). No significant difference could be detected between the different groups vs the control group; Control, the normal control group; 100 mg/kg, 100 mg/kg GTN- intraperitoneal treated group; 200 mg/kg, 200 mg/kg GTN- intraperitoneal treated group; 300 mg/kg, 300 mg/kg GTN- intraperitoneal treated group; 400 mg/kg, 400 mg/kg GTN- intraperitoneal treated group; 500 mg/kg, 500 mg/kg GTN- intraperitoneal treated group.

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