Toxicological Evaluation of a Mixture of Astragalus membranaceus and Panax notoginseng Root Extracts (InnoSlim®)

Table 5

Clinical chemistry in the 28-day study.

Group		ALT	AST	ALP	TBIL	CREA	UREA	GLUC	CHOL	Pi	Ca^++	Na^+	K^+	Cl^-	ALB	TPROT	A/G
(mg/kg bw/day)		[U/L]	[U/L]	[U/L]	[µmol/L]	[µmol/L]	[mmol/L]	[mmol/L]	[mmol/L]	[mmol/L]	[mmol/L]	[mmol/L]	[mmol/L]	[mmol/L]	[g/L]	[g/L]
Male
Control	Mean	55.00	91.60	165.20	1.26	24.70	8.28	6.50	2.40	2.54	2.78	145.06	4.66	98.57	44.01	61.96	2.5
(n = 10)	SD	6.73	13.65	22.29	0.36	3.16	0.65	0.50	0.57	0.26	0.10	1.11	0.28	1.11	1.80	3.22	0.2
400	Mean	50.30	86.70	175.50	1.27	24.30	7.96	6.71	2.24	2.42	2.73	144.95	4.42	98.95	44.12	60.95	2.6
(n = 10)	SD	9.74	10.36	26.71	0.44	1.89	0.81	0.41	0.23	0.16	0.06	1.17	0.21	1.18	1.11	1.98	0.1
800	Mean	44.80	81.50	179.90	1.34	22.70	7.51	6.17	2.45	2.71	2.79	144.66	4.53	97.78	44.40	62.29	2.5
(n = 10)	SD	5.39	7.71	24.28	0.45	2.21	0.96	0.49	0.40	0.16	0.06	1.45	0.12	0.94	1.09	2.17	0.2
	SS
1200	Mean	50.80	96.50	189.50	1.04	25.90	7.83	6.38	2.24	2.55	2.74	144.87	4.50	98.13	43.95	62.64	2.4
(n = 10)	SD	11.24	25.59	28.23	0.29	2.69	1.42	0.70	0.35	0.20	0.05	0.83	0.20	1.20	1.76	2.48	0.3
Test for Significance		DN	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS	NS
Historical Control Range		35–61	72–136	123–262	0.8–2.3	17–29	5.6–10.9	4.0–5.9	1.7–3.0	2.5–3.3	2.6–3.0	141.4–147.6	4.3–5.6	94.5–101.8	39.9–45.8	55.5–63.4	2.0–3.1
Female
0 (Control)	Mean	43.80	88.80	115.40	1.37	24.80	6.91	6.32	1.70	2.28	2.72	143.17	4.38	99.61	46.00	62.05	2.90
(n = 10)	SD	9.48	13.64	22.57	0.63	1.23	0.71	0.36	0.23	0.27	0.05	1.56	0.39	1.69	1.52	1.55	0.31
400	Mean	40.90	81.80	102.30	1.42	27.50	7.00	6.18	1.62	2.04	2.64	142.03	4.01	98.47	46.56	63.35	2.81
(n = 10)	SD	3.93	8.93	17.59	0.32	1.78	0.93	0.55	0.33	0.24	0.11	1.90	0.33	1.48	1.48	3.17	0.34
	SS
800	Mean	47.90	91.40	102.10	1.41	24.40	7.20	6.48	1.99	2.15	2.72	143.85	4.29	100.37	48.27	63.65	3.19
(n = 10)	SD	9.62	17.23	19.68	0.40	1.71	1.49	0.86	0.46	0.29	0.07	1.79	0.25	2.03	2.98	2.91	0.44
1200	Mean	42.00	85.50	102.50	1.34	25.30	7.39	6.73	2.09	2.11	2.68	142.59	4.34	99.40	47.11	64.01	2.81
(n = 10)	SD	3.33	17.06	23.46	0.30	2.58	1.42	0.80	0.24	0.39	0.08	1.20	0.30	1.77	1.88	2.56	0.30
	SS
Test for Significance		NS	NS	NS	NS	DN	NS	NS	DN	NS	DN	NS	DN	NS	NS	NS	NS
Historical Control Range		26–60	67–145	66–188	0.9–2.0	21.0–32.0	4.8–12.2	3.3–6.2	1.4–2.5	1.8–2.8	2.5–2.7	139.8–147.3	3.7–4.7	97–103.7	42.0–50.3	58.7–68.4	2.2–3.8

A/G, albumin to globulin ratio; ALB, albumin; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BAC, bile acids; Ca++, calcium; CHOL, cholesterol; Cl-, chloride; CREA, creatinine; DN, Duncan’s multiple range test; GLUC, glucose; K+, potassium; Na+, sodium; NS, not significant; Pi, inorganic phosphorous; SD, standard deviation; SS, statistically significant compared to control; TBIL, total bilirubin; TPROT, total protein.
p < 0.05; p < 0.01.