Research Article
Exposure of Fluoride with Streptozotocin-Induced Diabetes Aggravates Testicular Damage and Spermatozoa Parameters in Mice
Table 1
Assessment of spermatozoa parameters.
| Sperm parameters | Control | STZ | Fluoride | Fluoride + STZ |
| Motility (%) | 88.66 ± 3.82 | 55.83 ± 13.57a | 57.83 ± 7.75a | 23.33 ± 22.50a,b,d | Sperm concentration (106/ml) | 62.12 ± 11.43 | 40.43 ± 10.82a | 46 ± 8.02a | 15.81 ± 13.24a,b,d | Viability (%) | 86 ± 1.09 | 57.33 ± 8.93a | 48.5 ± 6.74a | 33 ± 23.84ab | GSI (%) | 0.592 ± 0.041 | 0.406 ± 0.018a | 0.476 ± 0.065a | 0.375 ± 0.072a,d | Body weight (g) | 49.17 ± 1.74 | 35.06 ± 3.82a | 30.56 ± 3.90a | 42.25 ± 1.92a,d | Number of seminiferous tubules | 290 ± 13.3 | 259 ± 8.2a | 268 ± 7.2a | 251 ± 9.1a,b | Seminiferous tubule diameter (mm) | 0.23 ± 0.020 | 0.19 ± 0.017a | 0.20 ± 0.019a | 0.15 ± 0.015a,b,d | Histology (Johnsen’s score) | 9.14 ± 1.81 | 7.33 ± 2.27a | 8.01 ± 1.61a,d | 6.41 ± 2.17a,b |
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Values are means ± SD. a( vs. control); b( STZ vs. fluoride + STZ); c( STZ vs. fluoride); d( fluoride + STZ vs. fluoride) (ANOVA and Bonferroni). |