Exposure of Fluoride with Streptozotocin-Induced Diabetes Aggravates Testicular Damage and Spermatozoa Parameters in Mice

Table 1

Assessment of spermatozoa parameters.

Sperm parameters	Control	STZ	Fluoride	Fluoride + STZ
Motility (%)	88.66 ± 3.82	55.83 ± 13.57^a	57.83 ± 7.75^a	23.33 ± 22.50^a,b,d
Sperm concentration (10^6/ml)	62.12 ± 11.43	40.43 ± 10.82^a	46 ± 8.02^a	15.81 ± 13.24^a,b,d
Viability (%)	86 ± 1.09	57.33 ± 8.93^a	48.5 ± 6.74^a	33 ± 23.84^ab
GSI (%)	0.592 ± 0.041	0.406 ± 0.018^a	0.476 ± 0.065^a	0.375 ± 0.072^a,d
Body weight (g)	49.17 ± 1.74	35.06 ± 3.82^a	30.56 ± 3.90^a	42.25 ± 1.92^a,d
Number of seminiferous tubules	290 ± 13.3	259 ± 8.2^a	268 ± 7.2^a	251 ± 9.1^a,b
Seminiferous tubule diameter (mm)	0.23 ± 0.020	0.19 ± 0.017^a	0.20 ± 0.019^a	0.15 ± 0.015^a,b,d
Histology (Johnsen’s score)	9.14 ± 1.81	7.33 ± 2.27^a	8.01 ± 1.61^a,d	6.41 ± 2.17^a,b

Values are means ± SD. ^a( vs. control); ^b( STZ vs. fluoride + STZ); ^c( STZ vs. fluoride); ^d( fluoride + STZ vs. fluoride) (ANOVA and Bonferroni).