Lyophilized B. subtilis ZB183 Spores: 90-Day Repeat Dose Oral (Gavage) Toxicity Study in Wistar Rats

Table 5

Summary of significant results in the thyroid hormone profile.

	Dose group (mg/kg/day)
	Males
	Control	20/10	200/100	2000/1000
T3 (ng/mL)	0.47 ± 0.14 (--)	0.54 ± 0.15 (--)	0.6 ± 0.31 (--)	0.52 ± 0.12 (--)
T4 (ng/mL)	24.55 ± 9.27 (--)	28.01 ± 12.5 (--)	29.1 ± 10.84 (--)	30.58 ± 14.08 (--)
TSH (ng/mL)	0.89 ± 0.44 (--)	0.96 ± 0.44 (--)	∗1.95 ± 0.74(119)	1.21 ± 0.51 (--)

Values are expressed as mean ± standard deviation. mg/kg/day, milligrams per kilogram body weight per day; ng/mL, nanograms per millilitre; ∗Significantly higher than the vehicle control group at , percent change given in brackets; (--) percent change not presented as difference is not significant.