Potential Toxicity of the Essential Oil from Minthostachys mollis: A Medicinal Plant Commonly Used in the Traditional Andean Medicine in Peru
Table 3
Haematological parameters of rats after treatment with repeated oral doses of Minthostachys mollis essential oil (Mm-EO) for 28 days.
Parameters
Control
Mm-EO 100
Mm-EO 250
Mm-EO 500
Males
RBC (×106/µL)
7.22 ± 0.17
7.42 ± 0.22
7.17 ± 0.29
n.d.
WBC (×103/µL)
8.10 ± 0.66
8.43 ± 0.85
8.50 ± 0.82
n.d.
Hemoglobin (g/dL)
14.73 ± 0.85
14.47 ± 0.47
14.33 ± 0.67
n.d.
Hematocrit (%)
46.67 ± 2.08
46.33 ± 3.55
45.97 ± 1.29
n.d.
Neutrophils (%)
18.67 ± 1.53
23.33 ± 3.51
24.67 ± 4.51
n.d.
Eosinophils (%)
2.67 ± 0.58
2.33 ± 0.58
2.67 ± 1.15
n.d.
Basophils (%)
1.33 ± 1.53
1.00 ± 1.00
1.00 ± 1.00
n.d.
Monocytes (%)
3.33 ± 0.58
3.00 ± 1.15
3.00 ± 1.00
n.d.
Lymphocytes (%)
74.00 ± 3.60
67.33 ± 6.56
68.67 ± 5.86
n.d.
Platelets (×103/µL)
707.33 ± 42.45
716.67 ± 35.11
748.33 ± 50.58
n.d.
Females
RBC (×106/µL)
7.17 ± 0.29
6.95 ± 0.25
6.91 ± 0.19
7.05 ± 0.17
WBC (×103/µL)
8.03 ± 0.45
8.73 ± 0.67
10.13 ± 2.95
10.26 ± 2.15
Hemoglobin (g/dL)
13.83 ± 1.89
13.67 ± 1.04
13.60 ± 1.65
13.47 ± 0.65
Hematocrit (%)
42.63 ± 5.73
42.53 ± 3.72
42.33 ± 3.49
42.23 ± 2.11
Neutrophils (%)
19.00 ± 1.53
23.67 ± 4.16
24.67 ± 4.16
27.33 ± 2.52
Eosinophils (%)
2.33 ± 0.58
1.67 ± 1.52
2.00 ± 1.00
2.00 ± 1.00
Basophils (%)
1.00 ± 1.00
0.67 ± 1.15
1.00 ± 1.00
0.67 ± 0.58
Monocytes (%)
2.67 ± 1.15
2.00 ± 1.00
2.67 ± 2.08
2.33 ± 0.58
Lymphocytes (%)
75.00 ± 2.64
72.00 ± 6.24
69.67 ± 6.51
67.67 ± 4.04
Platelets (×103/µL)
696.33 ± 26.95
747.00 ± 43.97
690.00 ± 29.31
738.33 ± 15.01
Values are expressed as Mean ± SD, significance when compared with control (). One-way ANOVA followed by Tukey test. RBC, Red blood cell; WBC, White blood cell. n.d., not determined because rats died in the first week of treatment.
