Potential Toxicity of the Essential Oil from Minthostachys mollis: A Medicinal Plant Commonly Used in the Traditional Andean Medicine in Peru
Table 2
Biochemical parameters of rats after treatment with repeated oral doses of Minthostachys mollis essential oil (Mm-EO) for 28 days.
Parameters
Control
Mm-EO 100
Mm-EO 250
Mm-EO 500
Males
AST (IU/L)
144.33 ± 6.81
161.67 ± 9.07
171.33 ± 11.37
n.d.
ALT (IU/L)
61.67 ± 13.61
80.33 ± 10.02
99.00 ± 11.53
n.d.
Alkaline phosphatase (IU/L)
175.67 ± 9.29
176.33 ± 4.04
181.00 ± 11.53
n.d.
Total bilirubin (mg/dL)
0.61 ± 0.13
0.62 ± 0.07
0.65 ± 0.06
n.d.
Total protein (g/dL)
7.23 ± 0.61
7.33 ± 0.61
7.53 ± 0.32
n.d.
Albumin (g/dL)
3.70 ± 0.36
3.90 ± 0.26
3.83 ± 0.49
n.d.
Cholesterol (mg/dL)
69.83 ± 4.25
65.40 ± 9.18
50.67 ± 8.33
n.d.
Triglycerides (mg/dL)
102.00 ± 11.79
79.33 ± 13.01
41.00 ± 8.89
n.d.
HDL (mg/dL)
30.77 ± 4.68
34.00 ± 5.14
35.13 ± 3.56
n.d.
LDL (mg/dL)
18.66 ± 2.55
15.53 ± 3.22
7.34 ± 2.19
n.d.
Glucose (mg/dL)
116.10 ± 8.65
108.43 ± 11.76
112.17 ± 7.52
n.d.
Urea (mg/dL)
34.00 ± 4.36
33.50 ± 3.12
29.83 ± 1.61
n.d.
Creatinine (mg/dL)
0.94 ± 0.08
0.85 ± 0.08
0.65 ± 0.04
n.d.
Females
AST (IU/L)
130.33 ± 5.50
144.33 ± 15.63
155.67 ± 12.89
168.33 ± 5.51
ALT (IU/L)
58.67 ± 9.71
83.67 ± 18.50
101.33 ± 11.37
109.00 ± 6.56
Alkaline phosphatase (IU/L)
174.00 ± 9.64
178.67 ± 17.61
177.67 ± 14.19
179.33 ± 6.03
Total bilirubin (mg/dL)
0.62 ± 0.14
0.62 ± 0.11
0.63 ± 0.15
0.66 ± 0.05
Total protein (g/dL)
7.23 ± 0.66
7.50 ± 0.36
7.20 ± 0.65
7.37 ± 0.49
Albumin (g/dL)
3.80 ± 0.20
3.73 ± 0.35
3.67 ± 0.31
3.65 ± 0.04
Cholesterol (mg/dL)
78.40 ± 10.05
58.00 ± 5.07
45.27 ± 5.00
42.90 ± 3.73
Triglycerides (mg/dL)
95.27 ± 11.08
82.03 ± 4.21
31.33 ± 3.21
30.13 ± 2.80
HDL (mg/dL)
33.13 ± 4.27
34.00 ± 5.60
34.03 ± 4.59
32.43 ± 2.89
LDL (mg/dL)
26.22 ± 5.15
7.59 ± 2.27
4.97 ± 0.73
4.44 ± 1.02
Glucose (mg/dL)
119.23 ± 6.49
113.23 ± 9.87
110.27 ± 14.14
115.07 ± 3.58
Urea (mg/dL)
35.97 ± 2.34
31.53 ± 2.84
28.47 ± 4.05
32.53 ± 5.06
Creatinine (mg/dL)
0.91 ± 0.08
0.82 ± 0.07
0.63 ± 0.06
0.60 ± 0.04
Values are expressed as Mean ± SD, significance when compared with control (). One-way ANOVA followed by Tukey test. AST, Aspartate aminotransferase; ALT, alanine aminotransferase; ALP, alkaline phosphatase; HDL, high-density lipoprotein; LDL, low-density lipoprotein. n.d., not determined because rats died in the first week of treatment.
