A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine
Table 9
Summary of organ weights.
Group (mg/kg bw/d)
Organ weight (g)
Body weight
Brain
Liver
Kidneys
Heart
Thymus
Spleen
Testes or uterus
Epididymides or ovaries
Adrenals
Thyroids
Males
Control ()
Mean
422.0
2.16
10.00
2.28
1.14
0.44
0.71
3.49
1.62
0.077
0.028
SD
17.52
0.16
0.96
0.20
0.09
0.12
0.10
0.34
0.09
0.01
0.01
180 ()
Mean
421.8
2.19
10.77
2.38
1.14
0.40
0.77
3.51
1.65
0.074
0.023
SD
25.26
0.12
0.99
0.26
0.19
0.08
0.08
0.34
0.20
0.02
0.01
±%
0.0
1
8
5
0
−8
9
1
2
−4
SS
300 ()
Mean
393.1
2.11
9.83
2.33
1.20
0.32
0.80
2.70
1.36
0.085
0.021
SD
28.39
0.10
0.77
0.26
0.14
0.06
0.11
0.74
0.15
0.01
0.01
±%
−7
−2
−2
3
5
−26
13
−23
−16
10
SS
375 ()
Mean
377.0
2.06
9.51
2.22
1.24
0.30
0.71
1.42
1.14
0.093
0.023
SD
26.43
0.14
0.99
0.25
0.22
0.05
0.10
0.68
0.12
0.01
0.00
±%
−11
−4
−5
−3
9
−31
1
−59
−30
20
SS
Females
Control ()
Mean
241.9
1.94
6.63
1.61
0.83
0.41
0.55
0.66
0.165
0.088
0.021
SD
15.55
0.07
0.70
0.21
0.07
0.06
0.11
0.09
0.036
0.012
0.003
180 ()
Mean
242.5
2.01
7.41
1.59
0.77
0.38
0.63
0.88
0.154
0.085
0.022
SD
14.74
0.11
0.62
0.14
0.05
0.05
0.10
0.28
0.027
0.018
0.006
±%
0
4
12
−1
−7
−8
15
32
−7
−4
9
SS
300 ()
Mean
250.4
1.98
7.07
1.56
0.92
0.33
0.61
0.58
0.148
0.092
0.022
SD
15.97
0.08
0.56
0.09
0.09
0.05
0.06
0.18
0.034
0.016
0.004
±%
4
2
7
−3
11
−20
11
−12
−10
4
6
SS
375 ()
Mean
247.3
1.96
7.16
1.55
0.95
0.31
0.61
0.57
0.151
0.095
0.022
SD
21.06
0.06
0.84
0.14
0.14
0.07
0.11
0.19
0.031
0.016
0.005
±%
2.2
0.7
8.0
−3.5
14.7
−25.0
11.1
−13.2
−8.3
6.9
8.3
SS
±%, percent deviation versus control, mg/kg bw/d, milligrams per kilogram body weight per day; SD, standard deviation; g, grams; SS, statistical significance; , number of animals. < 0.05; < 0.01.
