A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine
Table 5
Summary of food consumption.
Group (mg/kg bw/d)
Daily mean food consumption (g/animal/day) on weeks
1
2
3
4
5
6
7
8
9
10
11
12
13
Males
Control
Mean
25.0
25.2
26.4
26.9
25.8
25.9
26.9
25.7
24.2
25.3
23.8
25.4
24.1
SD
1.56
1.76
1.93
1.74
2.13
1.94
2.25
1.87
2.04
2.50
2.03
2.31
2.47
180
Mean
23.1
25.3
26.6
27.2
27.1
26.8
26.9
26.1
25.3
26.7
25.3
26.2
26.5
SD
1.52
1.70
2.13
1.82
1.88
2.16
2.27
2.24
1.88
1.65
1.45
1.59
1.84
±%
−7.7
0.4
0.9
1.1
5.1
3.3
0.1
1.7
4.8
5.9
6.3
3.2
10.2
SS
300
Mean
21.0
23.6
23.6
24.9
24.5
24.4
24.9
23.9
23.7
24.8
23.7
24.1
24.1
SD
1.72
1.43
2.52
1.22
1.16
1.40
1.69
1.47
1.40
1.23
1.47
1.93
2.21
±%
−16
−6
−11
−7
−5
−6
−7
−7
−2
−2
0
−5
0
SS
375
Mean
18.2
22.8
24.4
24.7
23.2
23.2
24.4
23.2
22.6
23.8
23.2
24.6
24.7
SD
2.76
2.48
1.62
1.43
1.86
1.71
1.54
1.94
1.86
2.04
2.15
2.76
2.21
10
10
10
10
10
10
9
9
9
9
9
9
9
±%
−27
−10
−8
−8
−10
−11
−9
−9
−7
−6
−2
−3
3
SS
Females
Control
Mean
17.3
17.6
17.8
18.9
19.5
19.3
19.7
19.0
17.9
19.4
18.6
20.5
20.0
SD
1.04
1.35
1.19
1.34
1.60
1.37
1.54
2.19
2.21
2.15
2.66
2.31
2.69
180
Mean
15.5
17.0
17.8
18.2
18.3
18.4
19.3
17.9
17.3
18.8
17.6
19.2
19.4
SD
0.53
0.88
1.13
1.10
1.48
1.46
1.51
1.16
1.14
1.63
1.18
1.48
1.69
±%
−10
−4
0
−4
−6
−5
−2
−6
−3
−3
−5
−6
−3
SS
300
Mean
14.6
16.5
17.8
18.4
18.4
18.7
19.5
18.1
17.8
18.8
18.9
20.5
19.6
SD
1.81
1.13
1.41
1.12
1.39
0.98
1.61
1.46
1.03
0.68
2.83
3.47
1.18
10
10
10
10
9
9
9
9
9
8
8
8
8
±%
−15
−6
0
−3
−6
−3
−1
−5
0
−3
2
0
−2
SS
375
Mean
14.4
17.5
17.6
18.8
18.7
18.6
19.6
18.7
17.7
18.9
18.2
19.8
19.9
SD
1.49
1.08
2.14
1.17
1.80
2.26
1.57
1.55
1.45
1.64
1.79
1.91
1.95
±%
−16.9
−0.6
−1.0
−0.5
−4.2
−3.9
−0.3
−1.7
−1.2
−2.9
−2.1
−3.3
−0.2
SS
±%, percent deviation versus control; mg/kg bw/d, milligrams per kilogram body weight per day; SD, standard deviation; g, grams; SS, statistical significance; , number of animals. < 0.05; < 0.01. unless otherwise stated.
