A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine
Table 10
Summary of organ weights relative to body weight (%).
Group (mg/kg bw/d)
Organ weight relative to body weight (%)
Brain
Liver
Kidneys
Heart
Thymus
Spleen
Testes or uterus
Epididymides or ovaries
Adrenals
Thyroids
Males
Control ()
Mean
0.512
2.371
0.538
0.271
0.104
0.167
0.825
0.384
0.018
0.007
SD
0.031
0.206
0.032
0.017
0.027
0.019
0.051
0.024
0.003
0.001
180 ()
Mean
0.519
2.551
0.564
0.269
0.096
0.183
0.831
0.391
0.018
0.005
SD
0.021
0.137
0.034
0.037
0.018
0.011
0.060
0.031
0.003
0.001
±%
1
8
5
−1
−8
10
1
2
−5
−19
SS
300 ()
Mean
0.540
2.502
0.593
0.305
0.082
0.203
0.692
0.347
0.022
0.005
SD
0.054
0.099
0.045
0.031
0.011
0.021
0.201
0.046
0.003
0.001
±%
5
6
10
13
−21
22
−16
−10
18
−20
SS
375 ()
Mean
0.549
2.519
0.588
0.329
0.079
0.189
0.379
0.304
0.025
0.006
SD
0.040
0.148
0.043
0.047
0.009
0.019
0.187
0.040
0.003
0.001
±%
7
6
9
22
−23
13
−54
−21
35
−5
SS
Females
Control ()
Mean
0.807
2.739
0.663
0.343
0.170
0.226
0.274
0.068
0.037
0.009
SD
0.064
0.215
0.058
0.032
0.023
0.041
0.036
0.014
0.005
0.002
180 ()
Mean
0.831
3.051
0.656
0.316
0.155
0.260
0.359
0.064
0.035
0.009
SD
0.040
0.110
0.049
0.023
0.017
0.034
0.107
0.013
0.007
0.002
±%
3
11
−1
−8
−9
15
31
−6
−4
7
SS
300 ()
Mean
0.794
2.828
0.625
0.367
0.132
0.244
0.233
0.059
0.037
0.009
SD
0.054
0.204
0.025
0.031
0.019
0.029
0.078
0.012
0.005
0.001
±%
−2
3
−6
7
−23
8
−15
−13
0
2
SS
375 ()
Mean
0.796
2.892
0.628
0.384
0.125
0.245
0.231
0.061
0.038
0.009
SD
0.071
0.200
0.039
0.048
0.023
0.026
0.068
0.013
0.006
0.002
±%
−1
6
−5
12
−27
8
−15
−10
5
5
SS
±%, percent deviation versus control, mg/kg bw/d, milligrams per kilogram body weight per day; SD, standard deviation; SS, statistical significance; , number of animals. < 0.05; < 0.01.
