A 90-Day Oral Toxicological Evaluation of the Methylurate Purine Alkaloid Theacrine

Table 1

Summary of necropsy findings.

Organ	Observations	Males (mg/kg bw/d)					Females (mg/kg bw/d)
		Control	180	300	375		Control	180	300		375
					Died early	Survivors			Died early	Survivors
	No macroscopic findings	10/10	9/10	6/10	0/1	0/9	9/10	6/10	0/2	6/8	3/10
Testes	Smaller than normal	0/10	0/10	4/10	1/1	9/9	/	/	/	/	/
Epididymides	Smaller than normal	0/10	0/10	4/10	0/1	9/9	/	/	/	/	/
Prostate	Smaller than normal	0/10	0/10	0/10	0/1	3/9	/	/	/	/	/
Adrenal glands	Pale	0/10	0/10	2/10	0/1	7/9	0/10	0/10	0/2	0/8	4/10
	Enlarged	0/10	0/10	0/10	0/1	0/9	0/10	0/10	1/2	0/8	0/10
Kidney (left side)	White compact formation on the surface	0/10	0/10	0/10	0/1	1/9	0/10	0/10	0/2	0/8	0/10
Skin	Alopecia	0/10	1/10	1/10	0/1	0/9	0/10	0/10	0/2	0/8	0/10
	Scar	0/10	0/10	1/10	0/1	2/9	0/10	0/10	0/2	0/8	0/10
	Cyanotic	0/10	0/10	0/10	1/1	0/9	0/10	0/10	0/2	0/8	0/10
Liver	Dark red	0/10	0/10	0/10	1/1	0/9	0/10	0/10	2/2	0/8	0/10
Lungs	Dark red	0/10	0/10	0/10	1/1	0/9	0/10	0/10	1/2	0/8	0/10
Thoracic cavity	Clotted blood near to the heart	0/10	0/10	0/10	1/1	0/9	0/10	0/10	0/2	0/8	0/10
Stomach	Empty	0/10	0/10	0/10	0/1	0/9	0/10	0/10	2/2	0/8	0/10
Intestines	Empty	0/10	0/10	0/10	0/1	0/9	0/10	0/10	1/2	0/8	0/10
Uterus	Hydrometra	/	/	/	/	/	1/10	4/10	1/2	2/8	4/10

Number of animals with observations/number of animals examined.
/, not examined; mg/kg bw/day, milligrams per kilogram body weight per day.