Effect of Metformin and Sitagliptin on Doxorubicin-Induced Cardiotoxicity in Rats: Impact of Oxidative Stress, Inflammation, and Apoptosis

Table 3

Effect of metformin or sitagliptin on the immunohistochemical enzymatic expression of COX-2, iNOS, and caspase-3 in DOX-induced cardiotoxicity in rats.

Parameter	Control	Metformin	Sitagliptin	DOX	Metformin/DOX	Sitagliptin/DOX
COX-2	1.25 ± 0.42	1.50 ± 0.54	1.25 ± 0.23	3.75 ± 0.43	2.00 ± 0.32	2.50 ± 0.58
iNOS	1.75 ± 0.28	1.50 ± 0.28	1.50 ± 0.28	3.50 ± 0.35	2.25 ± 0.36	2.75 ± 0.24
Caspase-3	1.25 ± 0.35	1.00 ± 0.42	1.25 ± 0.36	3.75 ± 0.52	1.75 ± 0.25	2.25 ± 0.37

Data were expressed as mean ± SEM of six observations.
Significantly different from control group ().
Significantly different from doxorubicin group ().