B-Lymphocytes from a Population of Children with Autism Spectrum Disorder and Their Unaffected Siblings Exhibit Hypersensitivity to Thimerosal
Figure 1
This figure shows the typical responses of a family of cells to thimerosal, measured on day 5 postinoculation. ASD = black, Twin = red, Sibling = blue, Control = green. (a) The percent control LDH values are plotted against increasing thimerosal concentrations for the 4 cell types. Arrows indicate LDH-G50 values with ASD = 314 nM, Twin = 648 nM, Sib = 373 nM, and Cont = 1000 nM. (b) The percent control XTT values are plotted against increasing thimerosal concentrations. XTT-G50 values are obtained using the mitochondrial XTT assay. (c) The percentage of cellular LDH that is accessible to lactate (i.e., percentage of dead and dying cells) is plotted against thimerosal. (d) Cell number and XTT reduction rates as a function of increasing thimerosal concentrations are shown. The plots obtained are “hockey stick” in shape.
