Cutting Edge PBPK Models and Analyses: Providing the Basis for Future Modeling Efforts and Bridges to Emerging Toxicology Paradigms

Figure 1

This figure represents, in simplistic fashion, major extrapolations between data that has been derived from in vitro isolated cell systems to interpretations of that data for cell-signaling pathways, the extrapolation of cell signaling results in regard to PBPK models that assign appropriate dose metrics and target organ concentrations, and finally the prediction of human risk from resulting models for a particular xenobiotic exposure.