Research Article
Safety Assessment of Zigbir®: A Polyherbal Formulation in Sprague-Dawley Rats
Table 7
Absolute organ weights (g; mean ± SD) in female rats after 90 days subchronic oral administration of Zigbir®.
| Organ | Control | 250 mg/kg | 500 mg/kg | 1000 mg/kg | Control recovery | 1000 mg/kg recovery |
| Terminal body weight | 232.66 ± 11.33 | 228.66 ± 14.67 | 216.17 ± 10.90 | 204.97 ± 6.75 | 268.78 ± 20.25 | 255.00 ± 12.83 | Brain | 1.843 ± 0.075 | 1.909 ± 0.079 | 1.805 ± 0.076 | 1.719 ± 0.075 | 1.837 ± 0.060 | 1.824 ± 0.054 | Liver | 6.940 ± 1.060 | 8.049 ± 0.478 | 7.062 ± 0.898 | 6.111 ± 0.531 | 8.379 ± 1.137 | 7.635 ± 0.708 | Kidneys | 1.610 ± 0.147 | 1.745 ± 0.199 | 1.541 ± 0.133 | 1.459 ± 0.099 | 1.536 ± 0.218 | 1.615 ± 0.124 | Adrenals | 0.0666 ± 0.016 | 0.0747 ± 0.007 | 0.0676 ± 0.007 | 0.0628 ± 0.01 | 0.0608 ± 0.002 | 0.0712 ± 0.009 | Ovaries | 0.0956 ± 0.02 | 0.1077 ± 0.014 | 0.0942 ± 0.017 | 0.0956 ± 0.013 | 0.146 ± 0.043 | 0.1488 ± 0.029 | Heart | 0.764 ± 0.059 | 0.797 ± 0.039 | 0.750 ± 0.091 | 0.736 ± 0.079 | 0.828 ± 0.128 | 0.833 ± 0.089 | Spleen | 0.754 ± 0.163 | 0.802 ± 0.096 | 0.935 ± 0.195 | 0.725 ± 0.099 | 1.010 ± 0.063 | 0.868 ± 0.104 | Lungs | 1.307 ± 0.167 | 1.598 ± 0.428 | 1.514 ± 0.409 | 1.317 ± 0.168 | 1.007 ± 0.105 | 1.02 ± 0.149 | Uterus | 0.545 ± 0.155
| 0.549 ± 0.132
| 0.563 ± 0.167
| 0.492 ± 0.088
| 0.478 ± 0.119
| 0.522 ± 0.049
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