Research Article
Safety Assessment of Zigbir®: A Polyherbal Formulation in Sprague-Dawley Rats
Table 6
Absolute organ weights (g; mean ± SD) in male rats after 90 days subchronic oral administration of Zigbir®.
| Organ | Control | 250 mg/kg | 500 mg/kg | 1000 mg/kg | Control recovery | 1000 mg/kg recovery |
| Terminal body weight | 348.86 ± 18.31 | 342.77 ± 28.01 | 332.90 ± 24.41 | 339.11 ± 32.83 | 367.32 ± 29.61 | 347.08 ± 37.86 | Brain | 1.978 ± 0.056 | 1.958 ± 0.059 | 1.898 ± 0.114 | 1.961 ± 0.058 | 1.965 ± 0.165 | 2.003 ± 0.045 | Liver | 11.621 ± 1.218 | 10.544 ± 1.264 | 10.307 ± 2.068 | 10.314 ± 1.801 | 8.769 ± 1.679 | 9.520 ± 1.092 | Kidneys | 2.587 ± 0.245 | 2.498 ± 0.225 | 2.371 ± 0.300 | 2.507 ± 0.290 | 2.472 ± 0.348 | 2.570 ± 0.237 | Adrenals | 0.0516 ± 0.009 | 0.0593 ± 0.009 | 0.056 ± 0.005 | 0.0524 ± 0.009 | 0.0578 ± 0.009 | 0.0516 ± 0.008 | Testes | 2.893 ± 0.263 | 2.834 ± 0.270 | 3.000 ± 0.341 | 2.849 ± 0.235 | 2.647 ± 0.259 | 2.848 ± 0.401 | Heart | 1.128 ± 0.100 | 1.046 ± 0.084 | 0.996 ± 0.141 | 1.008 ± 0.121 | 0.994 ± 0.113 | 1.057 ± 0.057 | Spleen | 1.048 ± 0.214 | 1.126 ± 0.340 | 1.203 ± 0.351 | 1.176 ± 0.182 | 1.086 ± 0.301 | 1.190 ± 0.235 | Lungs | 1.606 ± 0.236 | 1.769 ± 0.217 | 1.585 ± 0.340 | 1.612 ± 0.154 | 1.491 ± 0.261 | 1.317 ± 0.569 |
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