Research Article
Safety Assessment of Zigbir®: A Polyherbal Formulation in Sprague-Dawley Rats
Table 5
Clinical chemistry data (mean ± SD) of female rats after oral administration of Zigbir® for 90 days.
| Parameters | Control | 250 mg/kg | 500 mg/kg | 1000 mg/kg | Control recovery | 1000 mg/kg recovery |
| Total protein (g%) | 7.54 ± 0.38 | 7.54 ± 0.56 | 7.83 ± 0.53 | 7.55 ± 0.46 | 7.79 ± 0.35 | 7.64 ± 0.29 | Albumin (g%) | 3.40 ± 0.32 | 3.46 ± 0.43 | 3.18 ± 0.41 | 3.34 ± 0.48 | 3.29 ± 0.35 | 3.67 ± 0.25 | Bilirubin (mg%) | 0.68 ± 0.07 | 0.67 ± 0.10 | 0.73 ± 0.04 | 0.64 ± 0.08 | 0.64 ± 0.09 | 0.66 ± 0.06 | Blood sugar (mg%) | 92.10 ± 12.48 | 88.80 ± 13.95 | 93.80 ± 11.48 | 83.60 ± 8.57 | 91.80 ± 10.89 | 91.00 ± 7.28 | Triglycerides (mg%) | 104.70 ± 9.14 | 105.30 ± 9.04 | 102.50 ± 9.42 | 106.30 ± 7.79 | 102.40 ± 3.78 | 105.60 ± 3.21 | Cholesterol (mg%) | 63.20 ± 4.47 | 61.80 ± 6.61 | 64.50 ± 5.48 | 64.20 ± 4.98 | 66.20 ± 3.03 | 65.40 ± 5.94 | BUN (mg%) | 38.90 ± 4.82 | 41.60 ± 4.58 | 38.30 ± 4.97 | 36.80 ± 5.71 | 38.40 ± 7.37 | 41.40 ± 4.28 | Creatinine (mg%) | 0.98 ± 0.09 | 0.97 ± 0.12 | 0.98 ± 0.11 | 0.95 ± 0.07 | 0.97 ± 0.05 | 1.03 ± 0.10 | AST(IU/L) | 59.90 ± 5.51 | 61.20 ± 5.03 | 62.50 ± 4.55 | 63.50 ± 4.35 | 62.20 ± 8.32 | 65.80 ± 5.97 | ALT (IU/L) | 43.20 ± 6.36 | 42.40 ± 7.44 | 38.90 ± 7.99 | 39.50 ± 9.44 | 39.60 ± 6.80 | 37.60 ± 7.27 | ALP (IU/L) | 63.90 ± 7.06 | 66.90 ± 5.34 | 69.60 ± 8.28 | 108.80** ± 9.41 | 71.00 ± 9.08 | 71.60 ± 6.31 | γGT(U/L) | 15.50 ± 2.92 | 14.80 ± 4.32 | 15.90 ± 2.81 | 15.90 ± 3.54 | 15.80 ± 2.39 | 15.60 ± 3.51 | LDH (IU/L) | 358.50 ± 33.58 | 354.50 ± 31.02 | 371.50 ±16.57 | 359.60 ± 34.88 | 334.60 ± 26.69 | 369.80 ± 34.49 | CPK (IU/L) | 63.70 ± 4.22 | 63.20 ± 5.01 | 64.50 ± 4.50 | 62.60 ± 4.79 | 66.40 ± 3.13 | 65.00 ± 5.66 | Sodium (mmol/L) | 142.10 ± 5.30 | 138.80 ± 5.69 | 141.80 ± 6.20 | 139.70 ± 6.31 | 139.40 ± 3.36 | 136.00 ± 5.10 | Chloride (mmol/L) | 101.90 ± 3.51 | 101.80 ± 2.82 | 101.40 ± 3.63 | 101.20 ± 2.94 | 102.40 ± 1.67 | 102.20 ± 1.79 | Potassium (mmol/L) | 3.73 ± 0.15 | 3.51* ± 0.14 | 3.83 ± 0.15 | 3.68 ± 0.24 | 3.77 ± 0.08 | 3.79 ± 0.06 | Calcium (mg%) | 9.44 ± 0.60 | 9.41 ± 0.50 | 9.49 ± 0.67 | 9.47 ± 0.70 | 9.52 ± 0.50 | 9.98 ± 0.68 | Phosphorus (mg%) | 4.23 ± 0.31 | 4.11 ± 0.27 | 4.21 ± 0.39 | 4.30 ± 0.37 | 4.34 ± 0.44 | 4.00 ± 0.50 |
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P < 0.05 versus control group. P < 0.01 versus control group.
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