Thimerosal-Derived Ethylmercury Is a Mitochondrial Toxin in Human Astrocytes: Possible Role of Fenton Chemistry in the Oxidation and Breakage of mtDNA

<table>Mitochondrial superoxide production correlates with hydroxyl radical generation and mtDNA damage in normal human astrocytes. Thimerosal potentiates Fenton/Haber-Weiss chemistry in the mitochondrial matrix. Control NHAs and NHAs incubated for 1 hour with 14.4 <svg height="9.6750002" id="M49" style="vertical-align:-2.29482pt" version="1.1" viewbox="0 0 9.6374998 9.6750002" width="9.6374998" xmlns="http://www.w3.org/2000/svg">
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</svg>M Thimerosal. Production of ROS measured with the mitochondrial superoxide probe MitoSox (red), and measurement of HO<sup>•</sup> via hydroxyphenyl fluorescein (HPF) (green) in (a), 3′OH DNA ends with <i>dd</i>TUNEL (green) in (b), and blunt-ended DNA breaks (green) in (c).</table>

Journal of Toxicology

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Figure 5

Figure 5: Thimerosal-Derived Ethylmercury Is a Mitochondrial Toxin in Human Astrocytes: Possible Role of Fenton Chemistry in the Oxidation and Breakage of mtDNA 

Figure 5 | Thimerosal-Derived Ethylmercury Is a Mitochondrial Toxin in Human Astrocytes: Possible Role of Fenton Chemistry in the Oxidation and Breakage of mtDNA 