Diesel Engine Exhaust Initiates a Sequence of Pulmonary and Cardiovascular Effects in Rats

Table 4

Time course for protein-corrected health effect parameters measured in lung homogenate of F344 rats after DEE exposure or clean air as a control, represented as mean and 95% c.i. value ($n=10$, except for HO activity $t=4$, 18 and 24 h were $n=5$). ${}^{*}\text{,}$${}^{**}\text{,}$${}^{***}$ significantly different from control at $P<.05\text{,}$$<$.01, $<$.001, respectively.

		$T=4\hspace{0.17em}$h		$T=18$ h		$T=24$ h		$T=48$ h		$T=72$ h
Parameter		Control	DEE	Control	DEE	Control	DEE	Control	DEE	Control	DEE
GPx activity	Mean	16.8	22.8${}^{***}$	17.1	${24}^{***}$	19	19.4	21.1	20.1	18.8	19.6
	95% c.i.	16.0–17.6	21.8–23.8	16.6–17.7	23.1–24.9	17.5–20.4	18.8–20.0	19.8–22.3	19.3–20.8	17.9–19.7	18.4–20.8
SOD activity	Mean	1.18	1.53${}^{***}$	1.19	${1.65}^{***}$	1.23	1.32	1.35	1.41	1.29	1.29
	95% c.i.	1.09–1.26	1.46–1.60	1.14–1.25	1.50–1.80	1.09–1.37	1.24–1.40	1.25–1.46	1.32–1.50	1.20–1.37	1.20–1.37
MDA	Mean	0.198	0.284${}^{**}$	0.165	${0.301}^{***}$	0.186	${0.24}^{**}$	0.202	${0.137}^{***}$	0.231	${0.166}^{*}$
	95% c.i.	0.153–0.243	0.256–0.312	0.145–0.185	0.280–0.322	0.162–0.210	0.217–0.263	0.184–0.220	0.126–0.148	0.215–0.247	0.108–0.224
HO activity	Mean	2.47	2.43	1.75	${2.13}^{*}$	1.78	${2.60}^{***}$	1.48	${1.98}^{}$	1.33	${1.71}^{**}$
	95% c.i.	2.15–2.78	2.32–2.55	1.59–1.91	1.85–2.40	1.56–2.00	2.45–2.76	1.28–1.68	1.74–2.21	1.19–1.46	1.51–1.91