Diesel Engine Exhaust Initiates a Sequence of Pulmonary and Cardiovascular Effects in Rats

Figure 1

Oxidative stress and inflammation responses in samples from rats exposed to DEE. Relative response of markers, as depicted in legend boxes, at various time points ($t=4$, 18, 24, 48, and 72 h) after termination of a 2-hour exposure of rats ($n=10$ per time point and exposure) to DEE. (GSSG/GSH response is indicated by right y-axis). Relative response is defined as the mean value of the DEE exposed group divided by the mean value of the sham exposed group at the same time point. Error bars indicate the standard error of the mean, corrected for the error introduced by the normalization. ${}^{*}\text{,}$${}^{**}\text{,}$${}^{***}$ significantly different from control at $P<.05\text{,}$$<$.01, $<$.001, respectively.

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