Effects of Cytochrome P450 Inhibitors on Itraconazole and Fluconazole Induced Cytotoxicity in Hepatocytes

Figure 4

AST and ALT activities in rat hepatocytes exposed to various concentrations of itraconazole and fluconazole. ^a–dMeans with different superscript differ significantly (𝑃<.05). Values are mean ± sd of 3 separate experiments.

(a) AST activity (Fluconazole)

(b) AST activity (Itraconazole)

(c) ALT activity (Fluconazole)

(d) ALT activity (Itraconazole)