Higher Circulating Lymphocytes and the Incidence of Pre-eclampsia and Eclampsia

Table 2

Two-sample Mendelian randomization estimations showing the effects of immune cell traits on the risk of pre-eclampsia/eclampsia.

Outcomes	Exposures	Inverse-variance weighted
		OR (95% CI)	value	-statistic	value^a
Pre-eclampsia/eclampsia	Lymphocyte absolute count	1.53 (1.31-1.79)	1.15-07	0.001	9.87-01
	T cell absolute count	1.49 (1.28-1.73)	2.73-07	0.038	8.46-01
	CD28- CD25++ CD8+ T cell absolute count	1.83 (1.44-2.32)	7.11-07	NA	NA
Pre-eclampsia	Lymphocyte absolute count	1.50 (1.28-1.77)	9.18-07	0.007	9.34-01
	T cell absolute count	1.47 (1.25-1.72)	1.76-06	0.096	7.56-01
	CD28- CD25++ CD8+ T cell absolute count	1.nn (1.38-2.26)	6.55-06	NA	NA

OR: odds ratio; CI: confidence interval. ^a value < 0.05 indicates the presence of heterogeneity. ^b value < 0.05 indicates the presence of horizontal pleiotropy.