Higher Circulating Lymphocytes and the Incidence of Pre-eclampsia and Eclampsia
Table 2
Two-sample Mendelian randomization estimations showing the effects of immune cell traits on the risk of pre-eclampsia/eclampsia.
Outcomes
Exposures
Inverse-variance weighted
OR (95% CI)
value
-statistic
valuea
Pre-eclampsia/eclampsia
Lymphocyte absolute count
1.53 (1.31-1.79)
1.15-07
0.001
9.87-01
T cell absolute count
1.49 (1.28-1.73)
2.73-07
0.038
8.46-01
CD28- CD25++ CD8+ T cell absolute count
1.83 (1.44-2.32)
7.11-07
NA
NA
Pre-eclampsia
Lymphocyte absolute count
1.50 (1.28-1.77)
9.18-07
0.007
9.34-01
T cell absolute count
1.47 (1.25-1.72)
1.76-06
0.096
7.56-01
CD28- CD25++ CD8+ T cell absolute count
1.nn (1.38-2.26)
6.55-06
NA
NA
OR: odds ratio; CI: confidence interval. a value < 0.05 indicates the presence of heterogeneity. b value < 0.05 indicates the presence of horizontal pleiotropy.