Green Synthesis of Silver Nanoparticles Using Extracts of Ehretia cymosa and Evaluation of Its Antibacterial Activity in Cream and Ointment Drug Delivery Systems

Table 5

The zone of inhibition (mm) obtained with different concentrations of the E. cymosa for the crude extracts and silver nanoparticles loaded cream formulations.

Drugs tested	% concentration of the active ingredients	Strains of microorganisms used
		S. aureus		E. coli
		Clinical isolates	ATCC 25923	Clinical isolates	ATCC 25922
CB	0	2.4 ± 0.12	2.1 ± 0.10	2.2 ± 0.20	2.0 ± 0.08
ACC1	1	7.5 ± 0.16	7.2 ± 0.16	4.8 ± 0.15	4.8 ± 0.15
ACC2	1.5	7.4 ± 0.15	7.2 ± 0.10	5.0 ± 0.32	4.8 ± 0.32
ACC3	2	9.2 ± 0.05	8.9 ± 0.25	5.9 ± 0.05	5.6 ± 0.82
MCC1	1	8.8 ± 0.21	8.4 ± 0.90	5.6 ± 0.28	5.4 ± 0.10
MCC2	1.5	10.4 ± 0.22	10.5 ± 0.22	7.1 ± 0.17	6.9 ± 0.16
MCC3	2	12.2 ± 0.30	11.9 ± 0.35	8.6 ± 0.30	8.7 ± 0.30
ASC1	1	12.4 ± 0.13	12.0 ± 0.22	8.8 ± 0.56	8.6 ± 0.42
ASC2	1.5	13.0 ± 0.20	13.1 ± 0.82	9.5 ± 0.08	9.5 ± 0.08
ASC3	2	14.8 ± 0.18	14.2 ± 0.44	10.2 ± 0.46	10.1 ± 0.10
MSC1	1	14.6 ± 0.15	14.4 ± 0.50	11.0 ± 0.51	10.9 ± 0.50
MSC2	1.5	15.7 ± 0.72	15.0 ± 0.10	11.6 ± 0.80	11.5 ± 0.32
MSC3	2	17.5 ± 0.61	17.2 ± 0.50	12.8 ± 0.07	12.5 ± 0.15
CC	1	14.8 ± 0.08	14.6 ± 0.26	12.2 ± 0.17	12.2 ± 0.26

Note. CB: cream base (negative control), ACC1, ACC2, and ACC3: 1%, 1.5%, and 2% aqueous crude extract cream, respectively, MCC1, MCC2, and MCC3: 1%, 1.5%, and 2% methanol crude extract cream, respectively, ASC1, ASC2 and ASC3: 1%, 1.5%, and 2% aqueous SNPs cream, respectively, MSC1, MSC2, and MSC3: 1%, 1.5%, and 2% methanol SNPs cream, respectively, and CC: 1% ciprofloxacin cream (positive control).