and Relaxivities of Dendrons Based on a OEG-DTPA Architecture: Effect of Gd³⁺ Placement and Dendron Functionalization

Table 1

Relaxivities and per Gd³⁺ of different dendrons.

Compound	(mM^−1 s^−1)	(mM^−1 s^−1)
DOTAREM	4.00 ± 0.59	4.69 ± 0.33	1.17
D1	4.24 ± 0.07	5.14 ± 0.08^$	1.21
D2	3.98 ± 0.07	5.55 ± 0.54^$	1.39
D3	35.15 ± 1.40^*	40.48 ± 0.84^*	1.15
D4	16.08 ± 0.18^*	22.43 ± 0.42^*	1.39
D5	8.45 ± 0.31^*	11.44 ± 0.45^*	1.35
D6	12.28 ± 0.05^*	24.56 ± 0.62^*	2.00

< 0.05 for comparisons with DOTAREM; < 0.1 for comparisons with DOTAREM.