Review Article

Present Status and Perspectives on the Use of Alkylresorcinols as Biomarkers of Wholegrain Wheat and Rye Intake

Table 3

Correlations of plasma and urinary alkylresorcinol metabolites (DHBA and DHPPA) with different measurements of wholegrain intake from previously published studies.

NGenderCountryType of studyDietary assessment methodDiet exposure parameterAR metabolitePlasma/urineCorrelation valueReference

56FaFinlandFree-living5DFRbCereal fibreDHBAc24 h urine0.370.005[66]
56FFinlandFree-living5DFRCereal fibreDHPPAd24 h urine0.410.002[66]
56FFinlandFree-living5DFRCereal fibreDHBAPlasma0.41<0.01[96]
56FFinlandFree-living5DFRCereal fibreDHPPAPlasma0.46<0.01[96]
56FFinlandFree-living5DFRCereal fibreTotal AR metabolitesPlasma0.42<0.01[96]
60FFinlandFree-living5DFRRyeDHBAPlasma0.32<0.05[97]
60FFinlandFree-living5DFRRyeDHPPAPlasma0.39<0.01[97]
60FFinlandFree-living5DFRRyeTotal AR metabolitesPlasma0.33<0.05[97]
60FFinlandFree-living5DFRRyeDHBA24 h urine0.52<0.001[97]
60FFinlandFree-living5DFRRyeDHPPA24 h urine0.44<0.001[97]
60FFinlandFree-living5DFRRyeTotal AR metabolites24 h urine0.48<0.001[97]

aF: female
b5DFR: 5-day food record
cDHBA: 3,5-dihydroxybenzoic acid
dDHPPA: 3,5-dihydroxyphenylpropionoic acid.