Inhibition of Neutrophil Collagenase/MMP-8 and Gelatinase B/MMP-9 and Protection against Endotoxin Shock

Table 4

Peptide treatment strategy for the animal experiment in Figures 4(b), 4(c), or 4(d).

Group	Peptide administration strategy
G1 ( = 12 or 15)	LPS (100 μL^*, iv)
G2 ( = 12)	LPS (100 μL, iv), 5 minutes later, Regasepin 2 (100 μL^**, iv)
G3 ( = 12)	P2 (200 μL^#, ip), wait for some time^##, LPS (100 μL, iv)

LPS is dissolved in sterile 0.9% saline at a concentration of 2 μg/µL. Regasepin 2 was dissolved in sterile 0.9% saline at a concentration of 7 mg/mL. ^#The concentration of P2 was 15 mg/mL; ^##the time interval was 30, 60, or 90 minutes for the experiments shown in Figures 4(b), 4(c), or 4(d).