Recent Progress in Genetics and Epigenetics Research on Diabetic Nephropathy in Malaysia

Table 2

Shows differences in the odd ratio of the allele distribution among genetic variants.

SNP	Chromosome	Ensembl	Genes	Risk allele	Odd ratio (OD) 95% CI	Author, year
rs11643718	16q13	ENSG00000070915	SLC12A3	G/A	0.547 (0.308-0.973)	Abu Seman et al. 2014 [6]
rs1799987	3p21	ENSG00000160791	CCR5	G/A	6.71 (2.55-17.68) (Chinese)	Yahya et al., 2019 [10]
rs4073	4q13.3	ENSG00000169429	IL-8	T/A	1.57 (0.66-3.71) (Indians)	Yahya et al., 2019 [10]
rs4880	6q25.3	ENSG00000112096	MnSOD	C/T	2.16 (0.54–8.65) Malays, 2.8 (0.53–14.94) Chinese, 2.4 (0.69–2.84) Indians	Yahya et al., 2019 [11]
rs1799983	7q36.1	ENSG00000164867	NOS3	T/C	2.8 (0.29–28.32) Malays, 3.55 (0.36–35.03) Chinese, 3.16 (0.52–17.56) Indians	Yahya et al., 2019 [11]
rs2070744	7q36.1	ENSG00000164867	eNOS	T/C	0.64 (0.11-1.18) smoking, 0.57 (0.26-0.88) waist circumference	Yahya et al., 2019 [10]
D18S880 microsatelite	18q22.3	ENSG00000150656	CNDP1		2.46 (1.48–4.10) Malays, 2.26 (1.34–3.83) Chinese, 1.77 (1.18–2.65) Indians	Yahya et al., 2019 [11]
rs2346061	18q22.3	ENSG00000150656	CNDP1	A/C	1.94 (1.76–3.20) Indians	Yahya et al., 2019 [11]
rs8192678	4p15.2	ENSG00000109819	PPARGC1A	C/T	0.85 (0.64-1.05) sex, 0.68 (0.36-1.00) smoking, 1.90 (1.11-2.68) waist circumference	Ahmad et al., 2020 [13]
rs2237895	11p15.5	ENSG00000053918	KCNQ1	A/C	0.42 (0.01-0.84) smoking, 1.21 (0.66-1.78) waist circumference	Ahmad et al., 2020 [13]
rs2283228	11p15.5	ENSG00000053918	KCNQ1	A/C	1.21 (0.55-1.87) waist circumference	Ahmad et al., 2020 [13]
rs5498	19p13.2	ENSG00000090339	ICAM1	A/G	1.27 (1.01-1.61)	Abu Seman et al., 2015 [14]