Coagulation Function and Type 2 Diabetic Kidney Disease: A Real-World Observational Study

Table 2

Prediction of coagulation parameters for the risk of DKD before and after balancing confounding factors.

Significant risk factors	OR (95% CI)
Without adjustment
PT (s)	0.961 (0.912-1.013)	0.147
APTT (s)	1.017 (0.991-1.043)	0.201
TT (s)	1.231 (1.148-1.320)	<0.001
D-D (mg/L)	1.153 (1.046-1.271)	0.004
FIB (g/L)	2.604 (2.260-3.001)	<0.001
FDP (mg/L)	1.529 (1.395-1.676)	<0.001
After balancing age, gender, SBP, HbA1c, and TG
PT (s)	0.884 (0.789-0.990)	0.032
APTT (s)	1.025 (0.989-1.062)	0.174
TT (s)	1.266 (1.146-1.398)	<0.001
D-D (mg/L)	1.138 (0.990-1.307)	0.068
FIB (g/L)	2.141 (1.762-2.600)	<0.001
FDP (mg/L)	1.327 (1.181-1.492)	<0.001
After balancing age, gender, SBP, HbA1c, TG, sALB, CRP, and PLT
PT (s)	0.994 (0.925-1.067)	0.859
APTT (s)	1.010 (0.976-1.045)	0.578
TT (s)	1.121 (1.023-1.230)	0.015
D-D (mg/L)	0.945 (0.815-1.094)	0.448
FIB (g/L)	1.565 (1.289-1.901)	<0.001
FDP (mg/L)	1.203 (1.077-1.344)	0.001

Abbreviations: PT: prothrombin time; APTT: activated partial thromboplastin time; TT: thrombin time; FIB: fibrinogen; D-D: D-dimer; FDP: fibrinogen degradation products; SBP: systolic blood pressure; TG: serum triglyceride; HbA1c: hemoglobin A1c; CRP: c-reactive protein; PLT: platelet; sALB: serum albumin. Data are expressed as odds ratio, 95% confidence interval, and .