Research Article
Coagulation Function and Type 2 Diabetic Kidney Disease: A Real-World Observational Study
Table 2
Prediction of coagulation parameters for the risk of DKD before and after balancing confounding factors.
| Significant risk factors | OR (95% CI) | |
| Without adjustment | PT (s) | 0.961 (0.912-1.013) | 0.147 | APTT (s) | 1.017 (0.991-1.043) | 0.201 | TT (s) | 1.231 (1.148-1.320) | <0.001 | D-D (mg/L) | 1.153 (1.046-1.271) | 0.004 | FIB (g/L) | 2.604 (2.260-3.001) | <0.001 | FDP (mg/L) | 1.529 (1.395-1.676) | <0.001 |
| After balancing age, gender, SBP, HbA1c, and TG | PT (s) | 0.884 (0.789-0.990) | 0.032 | APTT (s) | 1.025 (0.989-1.062) | 0.174 | TT (s) | 1.266 (1.146-1.398) | <0.001 | D-D (mg/L) | 1.138 (0.990-1.307) | 0.068 | FIB (g/L) | 2.141 (1.762-2.600) | <0.001 | FDP (mg/L) | 1.327 (1.181-1.492) | <0.001 |
| After balancing age, gender, SBP, HbA1c, TG, sALB, CRP, and PLT | PT (s) | 0.994 (0.925-1.067) | 0.859 | APTT (s) | 1.010 (0.976-1.045) | 0.578 | TT (s) | 1.121 (1.023-1.230) | 0.015 | D-D (mg/L) | 0.945 (0.815-1.094) | 0.448 | FIB (g/L) | 1.565 (1.289-1.901) | <0.001 | FDP (mg/L) | 1.203 (1.077-1.344) | 0.001 |
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Abbreviations: PT: prothrombin time; APTT: activated partial thromboplastin time; TT: thrombin time; FIB: fibrinogen; D-D: D-dimer; FDP: fibrinogen degradation products; SBP: systolic blood pressure; TG: serum triglyceride; HbA1c: hemoglobin A1c; CRP: c-reactive protein; PLT: platelet; sALB: serum albumin. Data are expressed as odds ratio, 95% confidence interval, and . |