Coagulation Function and Type 2 Diabetic Kidney Disease: A Real-World Observational Study

Table 1

Baseline characteristics of study participants.

Variables	Total ()	Non-DKD ()	DKD ()
Age (years)	60 (53, 67)	58 (51, 65)	61 (53, 68)	<0.001
Gender, (%)				0.002
Female	1135 (42.0)	262 (48.0)	873 (40.5)
Male	1568 (58.0)	284 (52.0)	1284 (59.5)
SBP (mmHg)	140.00 (129.00, 155.00)	130.00 (120.00, 140.00)	140.00 (130.00, 160.00)	<0.001
DBP (mmHg)	80.00 (74.00, 90.00)	80.00 (72.00, 85.00)	80.00 (74.00, 90.00)	0.001
TC (mmol/L)	4.66 (3.88, 5.58)	4.58 (3.86, 5.16)	4.71 (3.88, 5.72)	<0.001
TG (mmol/L)	1.64 (1.15, 2.37)	1.51 (1.09, 2.09)	1.68 (1.17, 2.43)	<0.001
LDL-C (mmol/L)	2.68 (2.09, 3.35)	2.55 (2.10, 3.06)	2.72 (2.09, 3.44)	<0.001
HDL-C (mmol/L)	1.16 (0.98, 1.37)	1.17 (1.00, 1.34)	1.16 (0.97, 1.37)	0.612
HbA1c (%)	7.20 (6.30, 8.80)	7.60 (6.60, 9.40)	7.10 (6.20, 8.60)	<0.001
CRP (mg/L)	2.50 (1.51, 4.30)	2.36 (1.50, 3.95)	2.50 (1.52, 4.40)	0.193
PLT (10^9/L)	206.00 (171.00, 248.00)	209.00 (173.25, 241.75)	205.00 (170.00, 249.00)	0.879
eGFR (ml/min/1.73m^2)	80.00 (39.15, 101.00)	99.80 (89.70, 107.55)	65.10 (31.20, 97.40)	<0.001
sALB (g/L)	37.40 (33.00, 41.20)	40.05 (37.30, 43.10)	36.60 (31.80, 40.40)	<0.001
UACR (mg/g)	325.49 (24.13, 2377.97)	9.28 (4.78, 17.77)	866.67 (105.11, 3081.89)	<0.001
PT (s)	10.50 (10.00, 11.10)	10.60 (10.10, 11.20)	10.50 (10.00, 11.10)	0.001
APTT (s)	30.80 (28.80, 33.30)	30.70 (28.70, 32.90)	30.80 (28.80, 33.40)	0.198
TT (s)	14.80 (13.90, 15.75)	14.50 (13.70, 15.30)	14.80 (14.00, 15.80)	<0.001
D-D (mg/L)	0.28 (0.10, 1.13)	0.20 (0.07, 1.07)	0.29 (0.11, 1.17)	<0.001
FIB (g/L)	3.44 (2.93, 4.09)	3.01 (2.68, 3.47)	3.61 (3.05, 4.24)	<0.001
FDP (mg/L)	1.60 (0.90, 2.52)	1.16 (0.63, 1.90)	1.70 (0.97, 2.70)	<0.001

Abbreviations: SBP: systolic blood pressure; DBP: diastolic blood pressure; TC: total cholesterol; TG: triglyceride; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; HbA1c: hemoglobin A1c; CRP: c-reactive protein; PLT: platelet; eGFR: estimated glomerular filtration rate; sALB: serum albumin; UACR: urinary albumin-to-creatinine ratio; PT: prothrombin time; APTT: activated partial thromboplastin time; TT: thrombin time; FIB: fibrinogen; D-D: D-dimer; FDP: fibrinogen degradation products. Continuous variables are expressed as median (interquartile range), and categorical variables as count (percent). The between-group comparison was done using the test or Wilcoxon’s rank sum test, where appropriate.