Lactiplantibacillus plantarum NKK20 Increases Intestinal Butyrate Production and Inhibits Type 2 Diabetic Kidney Injury through PI3K/Akt Pathway

Table 3

Potential differential metabolites between the DKD group and NKK20 group.

No	Compounds	Formula	Library ID	m/z	R/T(min)	VIP		Change
1	Palmityl palmitate	C32H64O2	LMFA07010001	479.48	11.69	1.46	0.001	↓
2	Nonadecanoic acid	C19H38O2	HMDB00772	343.28	12.22	1.42	0.001	↓
3	DG(O-16 : 0/18 : 1(9Z))	C37H72O4	LMGL02020001	625.54	12.17	1.37	0.001	↓
4	15(S)-HETE	C20H32O3	HMDB03876	319.23	10.06	1.35	0.001	↑
5	N-docosahexaenoyl glutamic acid	C27H39NO5	LMFA08020089	502.28	9.53	1.31	0.001	↑
6	SM(d18 : 1/16 : 0)	C39H79N2O6P	LMSP03010003	747.56	9.68	1.30	0.001	↑
7	16-a-Hydroxypregnenolone	C21H32O3	HMDB00315	313.22	9.11	1.29	0.001	↓
8	PC(17 : 2(9Z,12Z)/0 : 0)	C25H48NO7P	LMGP01050127	504.31	9.57	1.29	0.001	↑
9	PC(18 : 1(9E)/0 : 0)	C26H52NO7P	LMGP01050030	566.34	10.21	1.28	0.001	↑
10	20-Oxo-leukotriene E4	C23H35NO6S	HMDB12642	452.21	9.97	1.27	0.001	↓
11	PC(16 : 0/0 : 0)	C24H50NO7P	LMGP01050018	494.32	10.50	1.24	0.001	↑
12	PC(O-18 : 1(1E)/0 : 0)	C26H54NO6P	LMGP01070008	552.37	10.42	1.24	0.001	↑
13	PC(O-16 : 0/0 : 0)	C24H52NO6P	LMGP01060010	526.35	10.25	1.21	0.001	↑
14	PC(19 : 3(10Z,13Z,16Z)/0 : 0)	C27H50NO7P	LMGP01050003	552.31	9.38	1.21	0.001	↑
15	PC(O-15 : 0/0 : 0)	C23H50NO6P	LMGP01060009	466.33	10.25	1.18	0.001	↑
16	SM(d16 : 1/17 : 0)	C38H77N2O6P	LMSP03010037	687.54	5.63	1.16	0.01	↑
17	13S-Hydroxyoctadecadienoic acid	C18H32O3	HMDB04667	295.23	9.75	1.13	0.01	↑
18	PC(18 : 2(9Z,12Z)/15 : 0)	C41H78NO8P	HMDB08132	742.54	11.66	1.12	0.01	↑
19	SM(d18:1/16 : 1)	C39H77N2O6P	LMSP03010041	745.55	10.74	1.12	0.01	↑
20	8-Keto palmitic acid	C16H30O3	LMFA01060055	539.43	12.59	1.10	0.01	↓
21	PC(20 : 4(5Z,8Z,11Z,14Z)/0 : 0)	C28H50NO7P	HMDB10395	588.33	9.42	1.08	0.01	↑