Plasma AGE and Oxidation Products, Renal Function, and Preeclampsia in Pregnant Women with Type 1 Diabetes: A Prospective Observational Study
Table 2
Cross-sectional associations (Pearson’s correlation coefficients) between plasma concentrations of AGE/oxidation-P and eGFR, during gestation and prior to the onset of preeclampsia.
DM+PE+
DM+PE-
DM-
value
value
value
-(Carboxymethyl)lysine (CML)
V1
-0.29
0.20
-0.500
0.018
0.00
0.99
V2
-0.30
0.17
0.18
0.43
0.05
0.86
V3
-0.483
0.023
0.06
0.78
0.24
0.33
Carboxyethyl-lysine (CEL)
V1
-0.16
0.48
-0.06
0.80
-0.45
0.07
V2
-0.463
0.030
-0.05
0.82
0.01
0.98
V3
-0.495
0.019
0.04
0.85
-0.01
0.97
Methylglyoxal-hydroimidazolone (MGH1)
V1
0.05
0.84
-0.14
0.54
-0.552
0.022
V2
-0.497
0.019
0.22
0.35
0.34
0.17
V3
-0.429
0.046
0.08
0.70
-0.08
0.75
3-Deoxyglucosone hydroimidazolones (3DGH)
V1
-0.12
0.61
-0.12
0.59
-0.40
0.12
V2
-0.43
0.06
-0.05
0.82
0.34
0.16
V3
-0.43
0.05
-0.08
0.73
-0.18
0.47
Glyoxal-hydroimidazolone (GH1)
V1
-0.12
0.60
-0.32
0.14
-0.632
0.006
V2
-0.512
0.015
0.07
0.78
0.02
0.94
V3
-0.663
0.001
-0.08
0.72
0.14
0.56
Methionine sulfoxide (MetSO)
V1
-0.10
0.67
0.34
0.12
-0.22
0.40
V2
0.01
0.97
0.26
0.25
0.37
0.13
V3
-0.38
0.09
-0.02
0.94
0.20
0.42
2-Aminoadipic acid (2-AAA)
V1
0.00
0.99
0.28
0.21
-0.20
0.44
V2
-0.26
0.24
0.34
0.13
0.552
0.018
V3
-0.41
0.06
0.16
0.46
0.01
0.98
Data are presented as the Pearson correlation coefficient, value. Boldface indicates values < 0.05 (statistically significant). Each AGE product and oxidation product is corrected by total protein concentration. Units for all: nmol/g.
