Increased Insulin Secretion and Glucose Effectiveness in Obese Patients with Type 2 Diabetes following Bariatric Surgery
Table 2
Minimal model outcome distributions.
Index
RYGB
SG
Control
SI (10-4 dL/kg/min per μU/mL)
Preoperative/control
5.0 [4.7, 7.5]§
4.4 [1.5, 8.7]§
22.3 [13.8, 38.7]
Postoperative
8.9 [4.1, 12.0]§
8.5 [5.0, 15.3]§
HEb (dimensionless)
Preoperative/control
0.48 [0.43, 0.55]
0.44 [0.38, 0.50]
0.51 [0.47, 0.58]
Postoperative
0.61 [0.59, 0.69]§
0.60 [0.60, 0.64]§
HEtot (dimensionless)
Preoperative/control
0.40 [0.37, 0.48]
0.39 [0.19, 0.40]
0.39 [0.32, 0.41]
Postoperative
0.54 [0.51, 0.59]§
0.50 [0.47, 0.58]§
(10-9 min-1)
Preoperative/control
9.0 [6.9, 11.5]§
9.8 [9.2, 10.9]§
5.3 [4.2, 5.6]
Postoperative
7.2 [6.0, 11.2]§
10.6 [8.4, 12.8]§
(10-9)
Preoperative/control
208.8 [112.8, 379.5]§
259.9 [205.6, 313.1]§
621.1 [391.1, 1250.5]
Postoperative
495.3 [330.7, 596.5]
633.0 [376.9, 733.5]
(10-9 min-1)
Preoperative/control
11.6 [9.2, 20.9]§
13.6 [8.2, 19.2]§
29.4 [20.7, 39.7]
Postoperative
19.8 [11.9, 25.5]
21.5 [12.8, 43.6]
(10-9 min-1)
Preoperative/control
13.3 [9.5, 22.1]§
14.8 [9.4, 20.4]§
33.2 [23.7, 49.3]
Postoperative
26.1 [14.2, 30.0]
26.7 [16.4, 48.5]
DId (10-14 dL/kg/min per pmol/L)
Preoperative/control
2887.5 [876.9, 3437.3]§
1461.4 [444.2, 3230.8]§
18349.3 [11958.0, 42693.5]
Postoperative
6087.3 [1737.7, 8284.3]§
9482.9 [2791.6, 13799.9]
DIs (10-14 dL/kg/min2 per pmol/L)
Preoperative/control
174.4 [80.8, 208.5]§
131.3 [34.9, 147.4]§
1037.4 [624.6, 1432.2]
Postoperative
255.4 [65.7, 426.7]§
386.6 [296.2, 427.1]§
DItot (10-14 dL/kg/min2 per pmol/L)
Preoperative/control
197.2 [83.2, 234.5]§
133.7 [38.5, 159.7]§
1172.2 [711.9, 1658.1]
Postoperative
293.5 [75.9, 487.8]§
419.7 [350.4, 531.2]§
GE (dL/kg/min)
Preoperative/control
0.041 [0.039, 0.045]§
0.032 [0.029, 0.044]§
0.059 [0.054, 0.066]
Postoperative
0.046 [0.044, 0.051]§
0.047 [0.040, 0.050]§
AUC(Ra0-60) (%)
Preoperative/control
84 [76, 112]§
95 [77, 115]§
67 [53, 72]
Postoperative
114 [108, 133]§
112 [109, 121]§
Values are reported as median [25th, 75th] percentile range. Significant compared to preoperative. §Significant compared to healthy control. RYGB: Roux-en Y gastric bypass; SG: sleeve gastrectomy.
