Journal of Diabetes Research

Research Article

Increased Insulin Secretion and Glucose Effectiveness in Obese Patients with Type 2 Diabetes following Bariatric Surgery

Table 1

Metabolic response rate distributions.
RYGBSGControl
#978
Age (years)49 [47, 53]49 [47, 51]49 [43, 61]
Sex (female)934
Preoperative
 BMI (kg/m2)41.9 [41.8, 45.5]§40.5 [39.6, 44.8]§25.4 [24.6, 26.2]
 TBW (kg)120.5 [117.2, 127.6]§129.6 [111.8, 143.2]§73.7 [69.4, 78.1]
 LBM (kg)64.4 [57.4, 65.7]§79.3 [57.4, 84.9]§48.9 [41.0, 57.9]
 Glucose
   (mmol/L)7.1 [6.7, 8.2]§6.5 [6.2, 7.8]§5.3 [4.9, 5.7]
   (mmol/L)13.5 [13.0, 15.1]§14.4 [12.2, 14.9]§9.8 [8.7, 11.1]
   (min)90.0 [71.3, 120.0]§60.0 [60.0, 82.5]45.0 [45.0, 60.0]
  AUC (mmol/L·min)24.2 [23.5, 25.7]§23.2 [22.0, 26.9]§15.9 [15.1, 17.8]
 Insulin
   (mmol/L)74.0 [65.6, 107.5]§117.5 [76.3, 155.5]§33.5 [28.5, 37.8]
   (pmol/L)309.0 [183.0, 408.0]351.0 [287.5, 554.8]377.0 [274.5, 489.0]
   (min)90.0 [56.3, 150.0]60.0 [37.5, 108.8]45.0 [30.0, 67.5]
  AUC (pmol/L·min)5.1 [3.1, 6.6]5.3 [4.9, 8.1]3.8 [2.5, 5.0]
 C-peptide
   (mmol/L)1091.5 [1011.0, 1468.5]§1229.5 [953.8, 1602.8]§480.8 [417.3, 517.0]
   (pmol/L)2606.0 [1835.0, 3506.3]2515.0 [2216.3, 3043.8]2271.0 [2047.0, 2775.0]
   (min)120.0 [112.5, 150.0]§120.0 [75.0, 120.0]§67.5 [52.5, 90.0]
  AUC (pmol/L·min)5396.0 [3726.2, 6360.9]4871.4 [4651.2, 5901.8]4079.4 [3368.6, 4528.8]
Postoperative
 BMI (kg/m2)38.1 [35.7, 39.5]§34.6 [33.4, 38.2]§
 TBW (kg)107.5 [99.0, 111.7]§109.9 [102.4, 122.5]§
 LBM (kg)59.2 [52.5, 60.9]§70.0 [57.6, 77.1]§
 Glucose
   (mmol/L)5.0 [4.9, 5.6]5.3 [4.7, 5.5]
   (mmol/L)13.1 [12.3, 13.3]§11.1 [11.0, 11.7]§
   (min)60.0 [45.0, 60.0]45.0 [45.0, 60.0]
  AUC (mmol/L·min)19.0 [17.9, 22.0]17.3 [16.7, 19.3]
 Insulin
   (mmol/L)36.0 [28.1, 52.5]57.5 [38.8, 83.1]§
   (pmol/L)424.0 [290.3, 653.5]497.0 [341.3, 1140.8]
   (min)45.0 [30.0, 60.0]30.0 [20.0, 56.3]
  AUC (pmol/L·min)3.3 [2.8, 4.7]4.1 [3.2, 9.2]
 C-peptide
   (mmol/L)703.5 [674.0, 864.5]§968.5 [585.3, 1064.0]§
   (pmol/L)3378.0 [1962.3, 3714.5]2785.0 [2408.5, 4148.0]
   (min)60.0 [45.0, 63.8]45.0 [33.8, 56.3]§
  AUC (pmol/L·min)4919.3 [3530.5, 5382.5]4501.7 [3881.3, 6727.9]
Values are reported as median [25th, 75th] percentile range. Significant compared to preoperative. §Significant compared to healthy control. RYGB: Roux-en Y gastric bypass; SG: sleeve gastrectomy.