The Composite Autonomic Symptom Score 31 Questionnaire: A Sensitive Test to Detect Risk for Autonomic Neuropathy

Table 5

COMPASS 31 score for definite/borderline CAN, no CAN, and results from monofilament test, for the entire population.

	COMPASS 31 score	AUC (95% CI)	Cut off: 16 p.; Sensitivity PPV	Specificity NPV	Cut off: 10 p.; Sensitivity PPV	Specificity NPV
CARTs
Definite/borderline CAN ()	14.3 (10.4-31.9)	0.69 (0.55-0.84)	0.33; 0.24	0.68; 0.78	0.83; 0.36	0.55; 0.92
No CAN ()	8.3 (3.2-21.5)
value	0.04
Monofilament test
Possible/likely DPN ()	15.5 (4.4-32.3)	0.60 (0.40-0.80)	0.40; 0.23	0.70; 0.87	0.70; 0.29	0.50; 0.83
No DPN ()	11.0 (4.3-21.8)
value	0.33

Data are medians with interquartile range. values using the Mann–Whitney test. The area under the curve (AUC) is estimated for predicting diagnostic accuracy. PPV = positive predictive value; NPV = negative predictive value; CARTs = cardiovascular reflex tests; CAN = cardiovascular autonomic neuropathy; DPN = diabetic peripheral neuropathy. Definite/borderline CAN = one or more pathological CARTs. Possible/probably DPN with <six sensations on monofilament test. A total of 14 participants did not complete the CARTs, five in the longstanding group, two in the early group, and seven in the control group.