From Diabetic Nephropathy to End-Stage Renal Disease: The Effect of Chemokines on the Immune System

Figure 3

Construction of PPI networks and identification of hub genes and hub CCRs. (a) PPI network constructed using DEGs. Each point represents a DEG. The size of the point and the shade of the color correspond to the size of the degree value. (b) The hub genes were screened by four algorithms (MCC, MNC, degree, and closeness). (c) Intersecting hub genes with CCRs to identify hub CCRs. CCRs: chemokines and chemokine receptors; PPI: protein-protein interaction.

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