Identification of Potentially Functional Circular RNA/Long Noncoding RNA-MicroRNA-mRNA Regulatory Networks Associated with Vascular Injury in Type 2 Diabetes Mellitus by Integrated Microarray Analysis

Figure 6

KCNQ1OT1, circ_0020316, and MAPK3 are upregulated, but miR-92a-2-5p is downregulated in peripheral blood of T2DM patients with macroangiopathy. (a) RT-qPCR detection of MAPK3 mRNA expression in peripheral blood of 50 T2DM patients with macroangiopathy and 30 normal healthy controls. (b) miR-4270, miR-92a-2-5p, miR-423-5p, and miR-613 expressions determined in peripheral blood of 50 T2DM patients with macroangiopathy and 30 normal healthy controls by RT-qPCR. (c) Correlation between miR-92a-2-5p and MAPK3 expressions assessed by Pearson’s methods. (d) TSIX, KCNQ1OT1, and LOC101926935 expressions in peripheral blood of 50 T2DM patients with macroangiopathy and 30 normal healthy controls measured by RT-qPCR. (e) Correlation between KCNQ1OT1 and MAPK3 expressions assessed by Pearson’s methods. (f) circ_0020316, circ_0091807, and circ_0091808 expressions in peripheral blood of 50 T2DM patients with macroangiopathy and 30 normal healthy controls measured by RT-qPCR. (g) Correlation between circ_0020316 and MAPK3 expressions evaluated by Pearson’s methods. , compared with normal healthy controls.

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