Association of MicroRNA-146a with Type 1 and 2 Diabetes and their Related Complications

Table 1

Clinical investigations on the correlation of miR-146a with T1D.

Type of diabetes	Tissue	Main findings	Ref.
T1D patients and normal controls	PBMC	Downregulation of miR-146a and overexpression of GADA	[38]
T1D patients and healthy controls	Plasma and PBMC	Increased expression of lncRNA SRAs may downregulate miR-146ain β-cells of T1D individuals	[34]
T1D, T2D patients and nondiabetic controls	Serum	Decreased miR-146aexpression in the serum of patients may serve as a potential biomarker via bioinformatic tools accompanied by clinical analysis	[35]
T1D patients and nondiabetic controls	Serum	C/G allele in the rs2910164 polymorphism is correlated with protection against T1D’s	[36]

T1D: type 1 diabetes; GADA: glutamic acid decarboxylase antibody; PBMC: peripheral blood mononuclear cells.