Factors Affecting Intensive Aflibercept Treatment Response in Diabetic Macular Edema: A Real-World Study

Table 2

Changes in central retinal thickness and best-corrected visual acuity in the whole cohort.

	Loading phase (monthly injection)					Maintenance phase (PRN regimen)
	Baseline	1 mo	2 mo	3 mo	4 mo	5 mo	6 mo	7 mo	8 mo	9 mo	10 mo	11 mo	12 mo
CRT (μm, )
value		0.021	0.028	0.014	0.014	0.011	0.042	0.022	0.010	0.010	0.036	0.168	0.012
BCVA (LogMAR, )
value		0.554	0.510	0.186	0.039	0.049	0.282	0.153	0.313	0.061	0.369	0.088	0.028

Statistically significant difference (), compared with preoperative values in repeated measures ANOVA. CRT: central retinal thickness; BCVA: best-corrected visual acuity; PRN: pro re nata; SD: standard deviation; mo: month.