Risk Factors for Nonalcoholic Fatty Liver Disease with Different Insulin Resistance in a Nonobese Chinese Population
Table 3
Factors associated with the presence of nonobese NAFLD in the group.
Model 1
Model 2
Model 3
Variables
OR (95% CI)
value
OR (95% CI)
value
OR (95% CI)
value
Gender
Female
1.00
1.00
—
—
Male
1.431 (1.066-1.920)
0.017
1.525 (1.124-2.071)
0.007
—
—
Age (years)
18-30
1.00
1.00
1.00
31-40
1.014 (0.668-1.620)
0.860
1.076 (0.689-1.678)
0.748
1.539 (0.871-2.717)
0.138
41-50
2.684 (1.753-4.108)
<0.001
2.748 (1.791-4.216)
<0.001
2.993 (1.744-5.137)
<0.001
>50
3.104 (2.035-4.736)
<0.001
3.270 (2.135-5.008)
<0.001
3.086 (1.810-5.261)
<0.001
Body mass index (kg/m2)
18.5-22.9
1.00
1.00
1.00
23.0-24.9
5.199 (3.861-7.002)
<0.001
4.996 (3.682-6.777)
<0.001
4.522 (3.104-6.588)
<0.001
Alanine aminotransferase (U/L)
≤17
1.00
—
—
>17
4.174 (3.076-5.665)
<0.001
4.044 (2.955-5.535)
<0.001
—
—
Aspartate aminotransferase (U/L)
≤18
1.00
1.00
1.00
>18
2.647 (1.995-3.512)
<0.001
2.553 (1.903-3.425)
<0.001
1.778 (1.231-2.569)
<0.001
Total cholesterol (mmol/L)
≤4.71
1.00
—
—
—
—
>4.71
1.287 (0.984-1.683)
0.065
—
—
—
—
High-density lipoprotein cholesterol (mmol/L)
≥1.36
1.00
1.00
—
—
<1.36
1.503 (1.148-1.969)
0.003
1.445 (1.087-1.921)
<0.001
—
—
Triglyceride (mmol/L)
≤0.9
1.00
1.00
1.00
>0.9
4.702 (3.431-6.443)
<0.001
4.783 (3.452-6.627)
<0.001
3.423 (2.429-4.823)
<0.001
Low-density lipoprotein cholesterol (mmol/L)
≤2.65
1.00
—
—
—
—
>2.65
1.297 (0.991-1.696)
0.058
—
—
—
—
Glucose (mmol/L)
≤5.25
1.00
1.00
1.00
>5.25
6.893 (5.109-9.299)
<0.001
6.798 (4.982-9.276)
<0.001
7.168 (4.935-10.409)
<0.001
Glycated hemoglobin (%)
≤5.5
1.00
1.00
1.00
>5.5
4.922 (3.669-6.602)
<0.001
4.691 (3.467-6.348)
<0.001
4.757 (2.601-5.429)
<0.001
Fasting insulin (uIU/mL)
≤3.89
1.00
—
—
—
—
>3.89
0.913 (0.604-1.380)
0.665
—
—
—
—
Homeostasis model assessment-beta (%)
≥47.1
1.00
1.00
—
<47.1
4.386 (3.160-6.089)
<0.001
4.261 (3.039-5.974)
<0.001
—
—
Abbreviations: 95% CI: 95% confidence interval; OR: odds ratio; †: the presence or absence of NAFLD was the dependent variable. Model 1: not adjusted for any confounding factors. Model 2: adjusted for gender and age. Model 3: adjusted for variables included in the model such as gender; age (years) 31 to 40, 41 to 50, and >50; BMI (kg/m2) 23.0 to 24.9; U/L; U/L; mmol/L; mmol/L; mmol/L; mmol/L; mmol/L; %; and %.
