Hypertriglyceridemic Waist Phenotype and Lipid Accumulation Product: Two Comprehensive Obese Indicators of Waist Circumference and Triglyceride to Predict Type 2 Diabetes Mellitus in Chinese Population
Table 3
Hazard ratios for the incidence of T2DM in different metabolic groups.
T2DM cases
Incidence density
Unadjusted model
Multivariable adjusted model#
HR (95% CI)
values
HR (95% CI)
values
High LAP
No
9,695
255
3.593
1.000 (ref)
—
1.000 (ref)
—
Yes
5,652
597
14.710
4.243 (3.660-4.913)
<0.001
4.094 (3.530-4.755)
<0.001
HTGW
No
13,662
576
5.781
1.000 (ref)
—
1.000 (ref)
—
Yes
2,055
291
19.958
3.611 (3.136-4.158)
<0.001
3.387 (2.929-3.916)
<0.001
Central obesity
No
10,208
307
4.106
1.000 (ref)
—
1.000 (ref)
—
Yes
5,509
560
14.192
3.585 (3.119-4.121)
<0.001
3.671 (3.163-4.260)
<0.001
Increased BP
No
8,705
311
4.858
1.000 (ref)
—
1.000 (ref)
—
Yes
7,012
556
11.075
2.281 (1.986-2.621)
<0.001
2.111 (1.820-2.448)
<0.001
Increased FPG
No
12,943
403
4.259
1.000 (ref)
—
1.000 (ref)
—
Yes
2,774
464
23.668
5.747 (5.028-6.567)
<0.001
5.532 (4.829-6.337)
<0.001
Increased TG
No
12,069
480
5.459
1.000 (ref)
—
1.000 (ref)
—
Yes
3,648
387
14.715
2.777 (2.429-3.175)
<0.001
2.719 (2.375-3.114)
<0.001
Reduced HDL-C
No
12,396
640
7.144
1.000 (ref)
—
1.000 (ref)
—
Yes
3,321
227
9.212
1.194 (1.026-1.390)
0.022
1.209 (1.034-1.413)
0.017
MS
No
13,120
473
4.937
1.000 (ref) (ref)
—
1.000 (ref) (ref)
—
Yes
2,597
394
21.402
4.419 (3.866-5.052)
<0.001
4.224 (3.671-4.860)
<0.001
Number of MS components
0
4,250
54
1.726
1.000 (ref)
—
1.000 (ref)
—
1
4,909
125
3.496
2.014 (1.463-2.771)
<0.001
1.996 (1.441-2.763)
<0.001
2
3,508
248
9.754
5.704 (4.249-7.656)
<0.001
5.728 (4.238-7.741)
<0.001
3
2,032
239
16.381
9.589 (7.137-12.884)
<0.001
9.437 (6.962-12.793)
<0.001
4
847
149
24.809
14.423 (10.564-19.691)
<0.001
14.846 (10.774-20.458)
<0.001
5
171
52
44.734
26.219 (17.914-38.372)
<0.001
24.652 (16.612-36.583)
<0.001
Incidence density, per 1000 person-years; BP: blood pressure; FPG: fast plasma glucose; TG: triglyceride; HDL-C: high-density lipoprotein cholesterol; MS: metabolic syndrome. #Adjusted for age, sex, smoking status, drinking status, physical activity, family history of T2DM, family income, and education. Grouped by optimal cutoff value () calculating through ROC curve analysis, 370 (247 for men and 123 for women) subjects were excluded because of LAP less than 0.
