Association between LXR-α and ABCA1 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus in a Chinese Han Population

Table 5

Genetic model analyses of the association between SNP rs2230806 and DKD patients without hypercholesterolemia with adjustment for age and gender.

	Genetic models	Genotype	DM	DKD	P	Without adjustment		With adjustment^¶
						OR (95% CI)		OR (95% CI)
rs2230806	Additive	AA	82 (25.0%)	68 (25.7%)	.042	1^#		1^#
		AG	181 (55.2%)	123 (46.4%)		0.819 (0.552-1.216)	.043	0.834 (0.560-1.243)	.031
		GG	65 (19.8%)	74 (27.9%)
	Dominant	AA	82 (25.0%)	69 (25.7%)	—	1^#	.854	1^#	.972
		AG+GG	248 (75.0%)	196 (74.3%)		0.966 (0.666-1.401)		0.993 (0.682-1.447)
	Recessive	AA+AG	276 (70.2%)	217 (72.1%)	—	1^#	.021	1^#	.013
		GG	65 (19.8%)	74 (27.9%)		1.568 (1.070-2.296)		1.634 (1.110-2.407)

. ^¶Adjustment for age and gender. ^#Reference category (odds ratio, 1.0). Abbreviations: CI: confidence interval; DKD: diabetic kidney disease; DM: diabetes mellitus; ORs: odds ratios.