Relationship between Urinary Liver-Type Fatty Acid-Binding Protein (L-FABP) and Sarcopenia in Spontaneously Diabetic Torii Fatty Rats

Figure 11

Molecular mechanism underlying the progression of sarcopenia in type 2 diabetes. Disruption to insulin/IGF-1-Akt signaling due to insulin resistance and low serum IGF-1 levels was considered to reduce muscle protein synthesis and to provoke abnormalities in muscle strength and mass in the SDT fatty rats. Furthermore, phosphorylation of AMPK due to reduced cellular uptake of glucose led to suppression of muscle protein synthesis. On the other hand, the involvement of muscle protein degradation signaling in muscle depression in the SDT group may be low.