Research Article
Exploring the Mechanism of Skeletal Muscle in a Tacrolimus-Induced Posttransplantation Diabetes Mellitus Model on Gene Expression Profiles
Table 4
Functional annotation of hub genes.
| Gene ID | Gene name | Description |
| Tpm3 | Tropomyosin alpha-3 chain | Binds to actin filaments in muscle and nonmuscle cells | Tnnc1 | Troponin C type 1 | Slow skeletal and cardiac muscles | Tnnt1 | Troponin T1 | The tropomyosin-binding subunit of troponin | Tnni3 | Troponin I, cardiac muscle | The inhibitory subunit of troponin | Hrh3 | Histamine Receptor H3 | Increase voltage-dependent calcium current in smooth muscles | Apln | Apelin | Activate specific signaling pathways that regulate insulin secretion | S1pr3 | Sphingosine-1-Phosphate Receptor 3 | A G-protein-coupled receptor for the bioactive sphingosine-1-phosphate, which is an important regulator of skeletal muscle function | Cxcl12 | C-X-C Motif Chemokine Ligand 12 | Plays a protective role after myocardial infarction |
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